IL17C Antikörper (AA 101-197)

Produktnummer ABIN747983

Produktdetails anti-IL17C Antikörper

Target: IL17C (Interleukin 17C (IL17C))

Bindungsspezifität: AA 101-197

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser IL17C Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Kreuzreaktivität: Human, Maus, Ratte

Homologie: Dog,Cow,Horse,Rabbit

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human IL-17C

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Referenzen für anti-IL17C Antikörper (ABIN747983)

Huang, Meng, Hong, Lin, Jin, Dong: "IL-17C is required for lethal inflammation during systemic fungal infection." in: Cellular & molecular immunology, Vol. 13, Issue 4, pp. 474-83, (2017) (PubMed).

Huang, Yuan, Zhu, Yin, Hong, Dong, Jin, Dong: "IL-17C/IL-17RE Augments T Cell Function in Autoimmune Hepatitis." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 198, Issue 2, pp. 669-680, (2016) (PubMed).

Details zu IL17C

Target: IL17C (Interleukin 17C (IL17C))

Andere Bezeichnung: IL-17C (IL17C Produkte)

Synonyme: IL17C antikoerper, il17-3 antikoerper, CX2 antikoerper, IL-17C antikoerper, IL-21 antikoerper, interleukin 17C antikoerper, interleukin 17c antikoerper, IL17C antikoerper, il17c antikoerper, Il17c antikoerper

Hintergrund:

Synonyms: CX2, IL-17C, Interleukin-17C, Cytokine CX2, IL17C, UNQ561/PRO1122

Background: Cytokine that plays a crucial role in innate immunity of the epithelium, including to intestinal bacterial pathogens, in an autocrine manner. Stimulates the production of antibacterial peptides and proinflammatory molecules for host defense by signaling through the NF-kappa-B and MAPK pathways. Acts synergically with IL22 in inducing the expression of antibacterial peptides, including S100A8, S100A9, REG3A and REG3G. Synergy is also observed with TNF and IL1B in inducing DEFB2 from keratinocytes. Depending on the type of insult, may have both protective and pathogenic properties, either by maintaining epithelial homeostasis after an inflammatory challenge or by promoting inflammatory phenotype. Enhanced IL17C/IL17RE signaling may also lead to greater susceptibility to autoimmune diseases.

Gen-ID: 27189

UniProt: Q9P0M4

Pathways: Cellular Response to Molecule of Bacterial Origin