LAG3 Antikörper (AA 201-300)

Produktnummer ABIN748508

Produktdetails anti-LAG3 Antikörper

Target: LAG3 (Lymphocyte-Activation Gene 3 (LAG3))

Bindungsspezifität: AA 201-300

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser LAG3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunocytochemistry (ICC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Kreuzreaktivität: Human, Maus

Homologie: Rat,Cow,Pig,Horse,Rabbit

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Lymphocyte Activation Gene 3

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Referenzen für anti-LAG3 Antikörper (ABIN748508)

Chen, Huang, Lu, Wang, Chi: "Antitumor effects of the silencing of programmed cell death ligand 1 in colorectal cancer via immunoregulation." in: Oncology reports, Vol. 40, Issue 6, pp. 3370-3380, (2018) (PubMed).

Parodi, Battaglia, Kalli, Ferrera, Conteduca, Tardito, Stringara, Ivaldi, Negrini, Borgonovo, Simonato, Traverso, Carmignani, Fenoglio, Filaci: "CD39 is highly involved in mediating the suppression activity of tumor-infiltrating CD8+ T regulatory lymphocytes." in: Cancer immunology, immunotherapy : CII, Vol. 62, Issue 5, pp. 851-62, (2013) (PubMed).

Details zu LAG3

Target: LAG3 (Lymphocyte-Activation Gene 3 (LAG3))

Andere Bezeichnung: Lymphocyte Activation Gene 3 (LAG3 Produkte)

Synonyme: CD223 antikoerper, LAG-3 antikoerper, Ly66 antikoerper, lymphocyte activating 3 antikoerper, lymphocyte-activation gene 3 antikoerper, LAG3 antikoerper, Lag3 antikoerper

Hintergrund:

Synonyms: CD223, Lymphocyte activation gene 3 protein, LAG-3, Lag3

Background: Lymphocyte-activation protein 3 (LAG-3), also known as CD223, belongs to the immunoglobulin superfamily and contains 4 extracellular Ig-like domains. LAG-3 binds to HLA class-II antigens and is involved in lymphocyte activation. It is found on the cell surface of activated NK and T-lymphocytes. The sequence data, exon/intron organization, and chromosomal localization all indicate a close relationship of LAG-3 to CD4.

Gen-ID: 297596

UniProt: Q5BK54

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Cancer Immune Checkpoints