ATG5 Antikörper (AA 101-200)

Produktnummer ABIN752413

Produktdetails anti-ATG5 Antikörper

Target: ATG5 (ATG5 Autophagy Related 5 (ATG5))

Bindungsspezifität: AA 101-200

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ATG5 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Kreuzreaktivität: Human, Maus, Ratte

Homologie: Dog,Cow,Pig,Horse,Chicken,Rabbit

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human APG5L

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
ELISA 1:500-1000
FCM 1:20-100
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Referenzen für anti-ATG5 Antikörper (ABIN752413)

Li, Li, Wang, Xie, Zhou, Meng, Ding, Ge, Chen: "Autophagy contributes to 4-Amino-2-Trifluoromethyl-Phenyl Retinate-induced differentiation in human acute promyelocytic leukemia NB4 cells." in: Toxicology and applied pharmacology, Vol. 319, pp. 1-11, (2017) (PubMed).

Lang, Qin, Li, Zhang, Fang, Hao: "Apoptotic Cell Death Induced by Resveratrol Is Partially Mediated by the Autophagy Pathway in Human Ovarian Cancer Cells." in: PLoS ONE, Vol. 10, Issue 6, pp. e0129196, (2015) (PubMed).

Zhang, Ma, Qi, Wei, Zhang, Li, Chiu: "P62 regulates resveratrol-mediated Fas/Cav-1 complex formation and transition from autophagy to apoptosis." in: Oncotarget, Vol. 6, Issue 2, pp. 789-801, (2015) (PubMed).

Tang, Li, Wei, Zhang, Chiu, Hasenmayer, Zhang, Zhang: "Resveratrol-induced apoptosis is enhanced by inhibition of autophagy in esophageal squamous cell carcinoma." in: Cancer letters, Vol. 336, Issue 2, pp. 325-37, (2013) (PubMed).

Song, Kou, Zou, Gao, Zeng, Xie: "Involvement of autophagy in tri-ortho-cresyl phosphate- induced delayed neuropathy in hens." in: Neurochemistry international, Vol. 64, pp. 1-8, (2013) (PubMed).

Details zu ATG5

Target: ATG5 (ATG5 Autophagy Related 5 (ATG5))

Andere Bezeichnung: APG5L (ATG5 Produkte)

Synonyme: APG5 antikoerper, APG5-LIKE antikoerper, APG5L antikoerper, ASP antikoerper, hAPG5 antikoerper, ATG5 antikoerper, CG1643 antikoerper, DmAtg5 antikoerper, Dmel\\CG1643 antikoerper, atg5 antikoerper, 2010107M05Rik antikoerper, 3110067M24Rik antikoerper, AW319544 antikoerper, Apg5l antikoerper, Atg5l antikoerper, C88337 antikoerper, Paddy antikoerper, apg5l antikoerper, zgc:100934 antikoerper, ATATG5 antikoerper, AUTOPHAGY 5 antikoerper, MKP11.20 antikoerper, MKP11_20 antikoerper, autophagy related 5 antikoerper, Autophagy-related 5 antikoerper, ATG5 autophagy related 5 homolog (S. cerevisiae) antikoerper, autophagy related 5 L homeolog antikoerper, similar to S. cerevisiae ATG5 (YPL149W) which nucleates preautophagosome formation as a conjugate with Atg12 antikoerper, autophagy protein Apg5 family antikoerper, ATG5 antikoerper, Atg5 antikoerper, atg5 antikoerper, atg5.L antikoerper, APG5 antikoerper

Hintergrund:

Synonyms: ASP, APG5, APG5L, hAPG5, APG5-LIKE, Autophagy protein 5, Apoptosis-specific protein, ATG5

Background: Involved in autophagic vesicle formation. Conjugation with ATG12, through a ubiquitin-like conjugating system involving ATG7 as an E1-like activating enzyme and ATG1 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. Involved in mitochondrial quality control after oxidative damage, and in subsequent cellular longevity. The ATG12-ATG5 conjugate also negatively regulates the innate antiviral immune response by blocking the type I IFN production pathway through direct association with RARRES3 and MAVS. Also plays a role in translation or delivery of incoming viral RNA to the translation apparatus. Plays a critical role in multiple aspects of lymphocyte development and is essential for both B and T lymphocyte survival and proliferation. Required for optimal processing and presentation of antigens for MHC II. Involved in the maintenance of axon morphology and membrane structures, as well as in normal adipocyte differentiation. Promotes primary ciliogenesis through removal of OFD1 from centriolar satellites and degradation of IFT2 via the autophagic pathway. May play an important role in the apoptotic process, possibly within the modified cytoskeleton. Its expression is a relatively late event in the apoptotic process, occurring downstream of caspase activity. Plays a crucial role in IFN-gamma-induced autophagic cell death by interacting with FADD.

Gen-ID: 9474

UniProt: Q9H1Y0

Pathways: Activation of Innate immune Response, Production of Molecular Mediator of Immune Response, Autophagie