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ATG4D Antikörper (AA 381-474)

ATG4D Reaktivität: Maus WB, ELISA, IHC (p), IF (cc), IF (p), IHC (fro) Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN752473
  • Target Alle ATG4D Antikörper anzeigen
    ATG4D (Autophagy related 4D Cysteine Peptidase (ATG4D))
    Bindungsspezifität
    • 15
    • 14
    • 8
    • 7
    • 7
    • 7
    • 6
    • 6
    • 6
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 381-474
    Reaktivität
    • 62
    • 41
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Maus
    Wirt
    • 78
    • 13
    • 1
    Kaninchen
    Klonalität
    • 79
    • 13
    Polyklonal
    Konjugat
    • 28
    • 8
    • 8
    • 8
    • 5
    • 5
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser ATG4D Antikörper ist unkonjugiert
    Applikation
    • 79
    • 36
    • 25
    • 25
    • 21
    • 15
    • 13
    • 6
    • 5
    • 2
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
    Kreuzreaktivität
    Maus
    Homologie
    Human,Rat,Dog,Cow,Pig
    Aufreinigung
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human ATG4D
    Isotyp
    IgG
    Top Product
    Discover our top product ATG4D Primärantikörper
  • Applikationshinweise
    WB 1:300-5000
    ELISA 1:500-1000
    IHC-P 1:200-400
    IHC-F 1:100-500
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 μg/μL
    Buffer
    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
    Konservierungsmittel
    ProClin
    Vorsichtsmaßnahmen
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    Haltbarkeit
    12 months
  • Target
    ATG4D (Autophagy related 4D Cysteine Peptidase (ATG4D))
    Andere Bezeichnung
    ATG4D (ATG4D Produkte)
    Synonyme
    APG4-D antikoerper, APG4D antikoerper, AUTL4 antikoerper, 9830134P12Rik antikoerper, Apg4d antikoerper, Atg4dl antikoerper, Autl4 antikoerper, apg4d antikoerper, autophagy related 4D cysteine peptidase antikoerper, autophagy related 4D, cysteine peptidase antikoerper, autophagy related 4D, cysteine peptidase L homeolog antikoerper, ATG4D antikoerper, Atg4d antikoerper, atg4d.L antikoerper
    Hintergrund

    Synonyms: APG4D, AUTL4, APG4-D, Cysteine protease ATG4D, AUT-like 4 cysteine endopeptidase, Autophagin-4, Autophagy-related cysteine endopeptidase 4, Autophagy-related protein 4 homolog D, ATG4D

    Background: Cysteine protease ATG4D: Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. Cleaves the C-terminal amino acid of ATG8 family proteins MAP1LC3 and GABARAPL2, to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. Has also an activity of delipidating enzyme for the PE-conjugated forms. Cysteine protease ATG4D, mitochondrial: Plays a role as an autophagy regulator that links mitochondrial dysfunction with apoptosis. The mitochondrial import of ATG4D during cellular stress and differentiation may play important roles in the regulation of mitochondrial physiology, ROS, mitophagy and cell viability.

    Gen-ID
    84971
    UniProt
    Q86TL0
    Pathways
    Autophagie
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