IFNAR1 Antikörper (AA 351-450)

Produktnummer ABIN754063

Produktdetails anti-IFNAR1 Antikörper

Target: IFNAR1 (Interferon alpha/beta Receptor 1 (IFNAR1))

Bindungsspezifität: AA 351-450

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser IFNAR1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Kreuzreaktivität: Human, Maus, Ratte

Homologie: Cow,Sheep

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human IFNAR1

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
ELISA 1:500-1000
FCM 1:20-100
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Details zu IFNAR1

Target: IFNAR1 (Interferon alpha/beta Receptor 1 (IFNAR1))

Andere Bezeichnung: IFNAR1 (IFNAR1 Produkte)

Synonyme: ifnar1 antikoerper, IFNAR1 antikoerper, CD118 antikoerper, Ifar antikoerper, Ifnar antikoerper, Ifrc antikoerper, Infar antikoerper, AVP antikoerper, IFN-alpha-REC antikoerper, IFNAR antikoerper, IFNBR antikoerper, IFRC antikoerper, IFN-R-1 antikoerper, interferon alpha and beta receptor subunit 1 antikoerper, interferon-alpha/beta receptor alpha chain-like antikoerper, interferon (alpha and beta) receptor 1 antikoerper, interferon alpha/beta receptor 1 antikoerper, IFNAR1 antikoerper, ifnar1 antikoerper, Ifnar1 antikoerper, LOC609830 antikoerper

Hintergrund:

Synonyms: AVP, IFRC, IFNAR, IFNBR, IFN-alpha-REC, Interferon alpha/beta receptor 1, IFN-R-1, IFN-alpha/beta receptor 1, Cytokine receptor class-II member 1, Cytokine receptor family 2 member 1, CRF2-1, Type I interferon receptor 1, IFNAR1

Background: Component of the receptor for type I interferons, including interferons alpha, IFNB1 and IFNW1 (PubMed:2153461, PubMed:7665574, PubMed:10049744, PubMed:14532120, PubMed:15337770, PubMed:21854986). Functions in general as heterodimer with IFNAR2 (PubMed:7665574, PubMed:10049744, PubMed:21854986). Type I interferon binding activates the JAK-STAT signaling cascade, and triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and the IFNR alpha- and beta-subunits themselves (PubMed:7665574, PubMed:21854986). Can form an active IFNB1 receptor by itself and activate a signaling cascade that does not involve activation of the JAK-STAT pathway (By similarity).

Gen-ID: 3454

UniProt: P17181

Pathways: JAK-STAT Signalweg, Hepatitis C