LRP5 Antikörper (AA 501-600)

Produktnummer ABIN754078

Produktdetails anti-LRP5 Antikörper

Target: LRP5 (Low Density Lipoprotein Receptor-Related Protein 5 (LRP5))

Bindungsspezifität: AA 501-600

Reaktivität: Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser LRP5 Antikörper ist unkonjugiert

Applikation: ELISA, Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Spezifität: This antibody will recognize LRP6 due to high sequence similarity.

Kreuzreaktivität: Maus

Homologie: Human,Rat,Dog,Cow,Horse,Chicken,Rabbit

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human LRP5

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Details zu LRP5

Target: LRP5 (Low Density Lipoprotein Receptor-Related Protein 5 (LRP5))

Andere Bezeichnung: LRP5 (LRP5 Produkte)

Synonyme: Xlrp5 antikoerper, bmnd1 antikoerper, evr1 antikoerper, evr4 antikoerper, hbm antikoerper, lr3 antikoerper, lrp5-A antikoerper, lrp7 antikoerper, oppg antikoerper, ops antikoerper, opta1 antikoerper, vbch2 antikoerper, LRP5 antikoerper, LRP6 antikoerper, BMND1 antikoerper, EVR1 antikoerper, EVR4 antikoerper, HBM antikoerper, LR3 antikoerper, LRP7 antikoerper, OPPG antikoerper, OPS antikoerper, OPTA1 antikoerper, VBCH2 antikoerper, mKIAA4142 antikoerper, low-density lipoprotein receptor-related protein 5 antikoerper, LDL receptor related protein 5 antikoerper, LDL receptor related protein 5 L homeolog antikoerper, low density lipoprotein receptor-related protein 5 antikoerper, LDL receptor related protein 5 like antikoerper, LOC100147353 antikoerper, LRP5 antikoerper, lrp5.L antikoerper, lrp5 antikoerper, Lrp5 antikoerper, LRP5L antikoerper

Hintergrund:

Synonyms: HBM, LR3, OPS, EVR1, EVR4, LRP7, OPPG, BMND1, LRP-5, OPTA1, VBCH2, Low-density lipoprotein receptor-related protein 5, LRP5

Background: Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in bone formation. The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalsomes and inhibiting AXIN1/GSK3-mediated phosphorylation and destruction of beta-catenin. Appears be required for postnatal control of vascular regression in the eye. Required for posterior patterning of the epiblast during gastrulation.

Gen-ID: 4041

UniProt: O75197

Pathways: WNT Signalweg, Stem Cell Maintenance, Positive Regulation of fat Cell Differentiation