TRIM25 Antikörper (AA 531-630)

Produktnummer ABIN754858

Produktdetails anti-TRIM25 Antikörper

Target: TRIM25 (Tripartite Motif Containing 25 (TRIM25))

Bindungsspezifität: AA 531-630

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TRIM25 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Kreuzreaktivität: Human, Maus

Homologie: Rat,Dog,Cow,Sheep

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human TRIM25

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Details zu TRIM25

Target: TRIM25 (Tripartite Motif Containing 25 (TRIM25))

Andere Bezeichnung: TRIM25 (TRIM25 Produkte)

Synonyme: zgc:55773 antikoerper, MGC130751 antikoerper, EFP antikoerper, RNF147 antikoerper, Z147 antikoerper, ZNF147 antikoerper, AA960166 antikoerper, AL022677 antikoerper, Zfp147 antikoerper, Efp antikoerper, Znf147 antikoerper, E3 ubiquitin/ISG15 ligase TRIM25 antikoerper, tripartite motif containing 25 antikoerper, E3 ubiquitin/ISG15 ligase TRIM25-like L homeolog antikoerper, microRNA 3614 antikoerper, tripartite motif-containing 25 antikoerper, LOC100146440 antikoerper, trim25 antikoerper, LOC100490741.L antikoerper, TRIM25 antikoerper, MIR3614 antikoerper, Trim25 antikoerper

Hintergrund:

Synonyms: EFP, Z147, RNF147, ZNF147, E3 ubiquitin/ISG15 ligase TRIM25, Estrogen-responsive finger protein, RING finger protein 147, Tripartite motif-containing protein 25, Ubiquitin/ISG15-conjugating enzyme TRIM25, Zinc finger protein 147, TRIM25

Background: Functions as a ubiquitin E3 ligase and as an ISG15 E3 ligase. Involved in innate immune defense against viruses by mediating ubiquitination of DDX58. Mediates 'Lys-63'-linked polyubiquitination of the DDX58 N-terminal CARD-like region which is crucial for triggering the cytosolic signal transduction that leads to the production of interferons in response to viral infection. Promotes ISGylation of 14-3-3 sigma (SFN), an adapter protein implicated in the regulation of a large spectrum signaling pathway. Mediates estrogen action in various target organs.

Gen-ID: 7706

UniProt: Q14258