DDR2 Antikörper (AA 245-350)

Produktnummer ABIN755218

Produktdetails anti-DDR2 Antikörper

Target: DDR2 (Discoidin Domain Receptor tyrosine Kinase 2 (DDR2))

Bindungsspezifität: AA 245-350

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser DDR2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc))

Kreuzreaktivität: Human, Maus, Ratte

Homologie: Dog,Cow,Pig,Horse,Chicken,Rabbit

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human CD167b/DDR2

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
ELISA 1:500-1000
FCM 1:20-100
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Referenzen für anti-DDR2 Antikörper (ABIN755218)

Zhu, Gillespie, Jackson: "NPY1-36 and PYY1-36 activate cardiac fibroblasts: an effect enhanced by genetic hypertension and inhibition of dipeptidyl peptidase 4." in: American journal of physiology. Heart and circulatory physiology, Vol. 309, Issue 9, pp. H1528-42, (2015) (PubMed).

Wang, Wang, Zhao, Li, Deng: "Angiotensin II upregulates K(Ca)3.1 channels and stimulates cell proliferation in rat cardiac fibroblasts." in: Biochemical pharmacology, Vol. 85, Issue 10, pp. 1486-94, (2013) (PubMed).

Details zu DDR2

Target: DDR2 (Discoidin Domain Receptor tyrosine Kinase 2 (DDR2))

Andere Bezeichnung: CD167b (DDR2 Produkte)

Synonyme: MIG20a antikoerper, NTRKR3 antikoerper, TKT antikoerper, TYRO10 antikoerper, AW495251 antikoerper, Ntrkr3 antikoerper, tyro10 antikoerper, DDR2 antikoerper, Tyro10 antikoerper, ddr2 antikoerper, si:ch211-193c2.1 antikoerper, discoidin domain receptor tyrosine kinase 2 antikoerper, discoidin domain receptor family, member 2 antikoerper, discoidin domain receptor family, member 2, like antikoerper, DDR2 antikoerper, Ddr2 antikoerper, ddr2l antikoerper

Hintergrund:

Synonyms: TKT, MIG2a, NTRKR3, TYRO1, Discoidin domain-containing receptor 2, Discoidin domain receptor 2, CD167 antigen-like family member B, Discoidin domain-containing receptor tyrosine kinase 2, Neurotrophic tyrosine kinase, receptor-related 3, Receptor protein-tyrosine kinase TKT, Tyrosine-protein kinase TYRO1, CD167b, DDR2

Background: Tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell differentiation, remodeling of the extracellular matrix, cell migration and cell proliferation. Required for normal bone development. Regulates osteoblast differentiation and chondrocyte maturation via a signaling pathway that involves MAP kinases and leads to the activation of the transcription factor RUNX2. Regulates remodeling of the extracellular matrix by up-regulation of the collagenases MMP1, MMP2 and MMP13, and thereby facilitates cell migration and tumor cell invasion. Promotes fibroblast migration and proliferation, and thereby contributes to cutaneous wound healing.

Gen-ID: 4921

UniProt: Q16832

Pathways: RTK Signalweg