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DDR2 Antikörper (AA 245-350)

DDR2 Reaktivität: Human, Maus, Ratte WB, ELISA, FACS, IF (cc) Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN755218
  • Target Alle DDR2 Antikörper anzeigen
    DDR2 (Discoidin Domain Receptor tyrosine Kinase 2 (DDR2))
    Bindungsspezifität
    • 9
    • 7
    • 6
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 245-350
    Reaktivität
    • 35
    • 24
    • 1
    • 1
    Human, Maus, Ratte
    Wirt
    • 41
    • 7
    Kaninchen
    Klonalität
    • 41
    • 7
    Polyklonal
    Konjugat
    • 27
    • 4
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser DDR2 Antikörper ist unkonjugiert
    Applikation
    • 34
    • 27
    • 21
    • 6
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA, Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc))
    Kreuzreaktivität
    Human, Maus, Ratte
    Homologie
    Dog,Cow,Pig,Horse,Chicken,Rabbit
    Aufreinigung
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human CD167b/DDR2
    Isotyp
    IgG
    Top Product
    Discover our top product DDR2 Primärantikörper
  • Applikationshinweise
    WB 1:300-5000
    ELISA 1:500-1000
    FCM 1:20-100
    IF(ICC) 1:50-200
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 μg/μL
    Buffer
    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
    Konservierungsmittel
    ProClin
    Vorsichtsmaßnahmen
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    Haltbarkeit
    12 months
  • Zhu, Gillespie, Jackson: "NPY1-36 and PYY1-36 activate cardiac fibroblasts: an effect enhanced by genetic hypertension and inhibition of dipeptidyl peptidase 4." in: American journal of physiology. Heart and circulatory physiology, Vol. 309, Issue 9, pp. H1528-42, (2015) (PubMed).

    Wang, Wang, Zhao, Li, Deng: "Angiotensin II upregulates K(Ca)3.1 channels and stimulates cell proliferation in rat cardiac fibroblasts." in: Biochemical pharmacology, Vol. 85, Issue 10, pp. 1486-94, (2013) (PubMed).

  • Target
    DDR2 (Discoidin Domain Receptor tyrosine Kinase 2 (DDR2))
    Andere Bezeichnung
    CD167b (DDR2 Produkte)
    Synonyme
    MIG20a antikoerper, NTRKR3 antikoerper, TKT antikoerper, TYRO10 antikoerper, AW495251 antikoerper, Ntrkr3 antikoerper, tyro10 antikoerper, DDR2 antikoerper, Tyro10 antikoerper, ddr2 antikoerper, si:ch211-193c2.1 antikoerper, discoidin domain receptor tyrosine kinase 2 antikoerper, discoidin domain receptor family, member 2 antikoerper, discoidin domain receptor family, member 2, like antikoerper, DDR2 antikoerper, Ddr2 antikoerper, ddr2l antikoerper
    Hintergrund

    Synonyms: TKT, MIG2a, NTRKR3, TYRO1, Discoidin domain-containing receptor 2, Discoidin domain receptor 2, CD167 antigen-like family member B, Discoidin domain-containing receptor tyrosine kinase 2, Neurotrophic tyrosine kinase, receptor-related 3, Receptor protein-tyrosine kinase TKT, Tyrosine-protein kinase TYRO1, CD167b, DDR2

    Background: Tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell differentiation, remodeling of the extracellular matrix, cell migration and cell proliferation. Required for normal bone development. Regulates osteoblast differentiation and chondrocyte maturation via a signaling pathway that involves MAP kinases and leads to the activation of the transcription factor RUNX2. Regulates remodeling of the extracellular matrix by up-regulation of the collagenases MMP1, MMP2 and MMP13, and thereby facilitates cell migration and tumor cell invasion. Promotes fibroblast migration and proliferation, and thereby contributes to cutaneous wound healing.

    Gen-ID
    4921
    UniProt
    Q16832
    Pathways
    RTK Signalweg
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