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NCEH1 Antikörper (AA 151-250)

NCEH1 Reaktivität: Human ELISA, IF (cc), IF (p), IHC (fro), IHC (p) Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN755752
  • Target Alle NCEH1 Antikörper anzeigen
    NCEH1 (Neutral Cholesterol Ester Hydrolase 1 (NCEH1))
    Bindungsspezifität
    • 6
    • 2
    • 1
    • 1
    • 1
    • 1
    AA 151-250
    Reaktivität
    • 21
    • 13
    • 6
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    Human
    Wirt
    • 20
    • 1
    Kaninchen
    Klonalität
    • 21
    Polyklonal
    Konjugat
    • 9
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser NCEH1 Antikörper ist unkonjugiert
    Applikation
    • 7
    • 6
    • 5
    • 5
    • 4
    • 4
    • 2
    • 2
    • 1
    ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Homologie
    Human,Mouse,Rat
    Aufreinigung
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human AADACL1
    Isotyp
    IgG
    Top Product
    Discover our top product NCEH1 Primärantikörper
  • Applikationshinweise
    ELISA 1:500-1000
    IHC-P 1:200-400
    IHC-F 1:100-500
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 μg/μL
    Buffer
    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
    Konservierungsmittel
    ProClin
    Vorsichtsmaßnahmen
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    Haltbarkeit
    12 months
  • Target
    NCEH1 (Neutral Cholesterol Ester Hydrolase 1 (NCEH1))
    Andere Bezeichnung
    AADACL1 (NCEH1 Produkte)
    Synonyme
    AADACL1 antikoerper, NCEH antikoerper, Aadacl1 antikoerper, B230106I24Rik antikoerper, CPO-BP antikoerper, Nceh antikoerper, RGD1311104 antikoerper, nceh antikoerper, aadacl1 antikoerper, MGC79479 antikoerper, nceh1b antikoerper, zgc:153038 antikoerper, zgc:92416 antikoerper, neutral cholesterol ester hydrolase 1 antikoerper, neutral cholesterol ester hydrolase 1 S homeolog antikoerper, neutral cholesterol ester hydrolase 1b, tandem duplicate 1 antikoerper, neutral cholesterol ester hydrolase 1a antikoerper, NCEH1 antikoerper, Nceh1 antikoerper, nceh1 antikoerper, nceh1.S antikoerper, nceh1b.1 antikoerper, nceh1a antikoerper
    Hintergrund

    Synonyms: Arylacetamide deacetylase like 1, Arylacetamide deacetylase-like 1, Kiaa1363, NCEH, Nceh1, NCEH1_HUMAN, Neutral cholesterol ester hydrolase 1, Neutral cholesterol ester hydrolase.

    Background: The assembly of very-low-density lipoproteins (VLDLs) in the secretory apparatus of the hepatocyte relies on the mobilization of triacylglycerol (TAG) from the cytosolic pool by lipolysis and re-esterification. However, some of the re-esterified TAG products are returned to the cytosolic pool in the liver, which protects vulnerable body tissues from excess lipotoxic non-esterified fatty acids in the plasma. Some of the lipases involved in this process include arylacetamide deacetylase (AADAC) and its related proteins AADACL1 and AADACL2. AADAC, a single pass type II membrane protein of the endoplasmic reticulum, is expressed in hepatocytes, intestinal mucosal cells, pancreas and adrenal gland. It plays an important role in the metabolic activation of arylamine substrates to ultimate carcinogens. AADACL1 hydrolyzes the metabolic intermediate 2-acetyl monoalkylglycerol, and its inactivation results in disruption of ether lipid metabolism in cancer cells and impaired cell migration and tumor growth.

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