ADAM11 Antikörper (AA 351-450) (Biotin)

Produktnummer ABIN758743

Produktdetails anti-ADAM11 Antikörper (Biotin)

Target: ADAM11 (ADAM Metallopeptidase Domain 11 (ADAM11))

Bindungsspezifität: AA 351-450

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ADAM11 Antikörper ist konjugiert mit Biotin

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Kreuzreaktivität: Human, Maus

Homologie: Rat,Cow,Sheep

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human ADAM11

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C for 12 months.

Haltbarkeit: 12 months

Details zu ADAM11

Target: ADAM11 (ADAM Metallopeptidase Domain 11 (ADAM11))

Andere Bezeichnung: ADAM11 (ADAM11 Produkte)

Synonyme: DKFZp459F101 antikoerper, AW060611 antikoerper, Mdc antikoerper, MDC antikoerper, mdc antikoerper, mdc11a antikoerper, xMDC11 antikoerper, ADAM metallopeptidase domain 11 antikoerper, a disintegrin and metallopeptidase domain 11 antikoerper, ADAM metallopeptidase domain 11 L homeolog antikoerper, ADAM11 antikoerper, adam11 antikoerper, Adam11 antikoerper, adam11.L antikoerper

Hintergrund:

Synonyms: A disintegrin and metalloproteinase domain 11, ADA11_HUMAN, MDC, Metalloproteinase like, disintegrin like, and cysteine rich protein.

Background: ADAM11 was first described as MDC (Metalloproteinase-like disintergin-like cysteine-rich protein) from analysis of human brain libraries, in search of brain-specific proteins. Two splice variants with different carboxyterminal ends were described. The message was found only in the brain in this publication. Another group identified ADAM11 in the human brain, where ADAM11 was thought to be involved in cell migration and spatial patterning. ADAM11 was mapped to 17q21.3, a region of interest for breast cancer, and mutations in ADAM11 are associated with some breast cancers. Retinoic acid caused a doubling in ADAM11 message levels over 24 hours in NT2/D1 cells, a human embryonic carcinoma cell line. ADAM11 null mutant mice have deficits in spatial learning and motor coordination, although they did have normal cell migration and differentiation during development. ADAM11 is a member of the ADAMs family (A Disintegrin And Metalloproteinase), but does not contain the canonical HExxHxxxxH zinc-binding metalloproteinase catalytic site. The domain structure of the full-length ADAM11 includes a signal sequence, propeptide domain, metalloproteinase-like domain, disintegrin-like domain, cys-rich domain, EGF-like domain, a spacer region, then the transmembrane domain and a short cytoplasmic domain.

Gen-ID: 4185