MFSD2A Antikörper (AA 331-430)

Produktnummer ABIN762026

Produktdetails anti-MFSD2A Antikörper

Target: MFSD2A (Major Facilitator Superfamily Domain Containing 2A (MFSD2A))

Bindungsspezifität: AA 331-430

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MFSD2A Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Kreuzreaktivität: Human, Maus, Ratte

Homologie: Dog,Cow,Pig,Horse,Chicken,Rabbit

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human MFSD2A

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
ELISA 1:500-1000
FCM 1:20-100
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Referenzen für anti-MFSD2A Antikörper (ABIN762026)

Díaz-Carballo, Klein, Acikelli, Wilk, Saka, Jastrow, Wennemuth, Dammann, Giger-Pabst, Khosrawipour, Rassow, Nienen, Strumberg: "Cytotoxic stress induces transfer of mitochondria-associated human endogenous retroviral RNA and proteins between cancer cells." in: Oncotarget, Vol. 8, Issue 56, pp. 95945-95964, (2017) (PubMed).

Details zu MFSD2A

Target: MFSD2A (Major Facilitator Superfamily Domain Containing 2A (MFSD2A))

Andere Bezeichnung: Mfsd2a (MFSD2A Produkte)

Synonyme: 1700018O18Rik antikoerper, Mfsd2 antikoerper, RGD1310174 antikoerper, MFSD2 antikoerper, NLS1-A antikoerper, Sodium-dependent LPC symporter 1-A antikoerper, mfsd2a antikoerper, zgc:101615 antikoerper, mfsd2 antikoerper, NLS1-B antikoerper, Sodium-dependent LPC symporter 1-B antikoerper, mfsd2b antikoerper, zgc:101069 antikoerper, major facilitator superfamily domain containing 2A antikoerper, major facilitator superfamily domain containing 2aa antikoerper, major facilitator superfamily domain containing 2A L homeolog antikoerper, major facilitator superfamily domain containing 2ab antikoerper, MFSD2A antikoerper, mfsd2a antikoerper, Mfsd2a antikoerper, mfsd2aa antikoerper, mfsd2a.L antikoerper, mfsd2ab antikoerper

Hintergrund:

Synonyms: NLS1, MFSD2, Sodium-dependent lysophosphatidylcholine symporter 1, Sodium-dependent LPC symporter 1, Major facilitator superfamily domain-containing protein 2A, MFSD2A, HMFN0656, PP9177, UNQ300/PRO341

Background: Sodium-dependent lysophosphatidylcholine (LPC) symporter, which plays an essential role for blood-brain barrier formation and function. Specifically expressed in endothelium of the blood-brain barrier of micro-vessels and transports LPC into the brain. Transport of LPC is essential because it constitutes the major mechanism by which docosahexaenoic acid (DHA), an omega-3 fatty acid that is essential for normal brain growth and cognitive function, enters the brain. Transports LPC carrying long-chain fatty acids such LPC oleate and LPC palmitate with a minimum acyl chain length of 14 carbons. Does not transport docosahexaenoic acid in unesterified fatty acid. Specifically required for blood-brain barrier formation and function, probably by mediating lipid transport. Not required for central nervous system vascular morphogenesis (By similarity). Acts as a transporter for tunicamycin, an inhibitor of asparagine-linked glycosylation. In placenta, acts as a receptor for ERVFRD-1/syncytin-2 and is required for trophoblast fusion (PubMed:18988732).

Gen-ID: 84879

UniProt: Q8NA29