TRMT12 Antikörper (N-Term)

Produktnummer ABIN783482

Produktdetails anti-TRMT12 Antikörper

Target: TRMT12 (tRNA Methyltransferase 12 Homolog (TRMT12))

Bindungsspezifität: N-Term

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TRMT12 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Enzyme Immunoassay (EIA)

Spezifität: This antibody detects TRMT12 at N-term. TYW2 antibody is predicted to not cross-react with other TYW protein family members. At least two isoforms of TYW2 are known to exist, this antibody will detect both isoforms.

Kreuzreaktivität (Details): Species reactivity (tested):Human, mouse

Aufreinigung: Affinity chromatography purified via peptide column

Immunogen: 19 amino acid peptide near the amino terminus of human TYW2

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS containing 0.02 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at 2 - 8 °C for up to three months or (in aliquots) at -20 °C for longer.

Details zu TRMT12

Target: TRMT12 (tRNA Methyltransferase 12 Homolog (TRMT12))

Andere Bezeichnung: TRMT12 (TRMT12 Produkte)

Synonyme: 4632406N01Rik antikoerper, AI449275 antikoerper, Tyw2 antikoerper, TRM12 antikoerper, TYW2 antikoerper, RGD1307127 antikoerper, trmt12 antikoerper, tRNA methyltranferase 12 antikoerper, tRNA methyltransferase 12 homolog antikoerper, tRNA methyltransferase 12 antikoerper, tRNA methyltransferase 12 homolog (S. cerevisiae) antikoerper, Trmt12 antikoerper, TRMT12 antikoerper, trmt12 antikoerper

Hintergrund: TYW2, also known as TRM12, is an enzyme that participates in the wybutosine-tRNA (Phe) biosynthesis pathway. Wybutosine (yW) is a hypermodified guanosine at the 3-prime position adjacent to the anticodon of phenylalanine tRNA that stabilizes codon-anticodon interactions during decoding on the ribosome. TYW2 is involved in a multistep enzymatic reaction that stabilizes codon-anticodon base-pairing during the ribosomal decoding process, thereby ensuring correct translation. TYW2 was found to be amplified in 7 of 8 breast cancers cell lines analyzed, and qPCR analysis of 30 breast tumors showed overexpression of TYW2 mRNA of over 2-fold in 26, suggesting that TYW2 may play a role in breast cancer.Synonyms: TRM12, TYW2, tRNA methyltransferase 12, tRNA wybutosine-synthesizing protein 2 homolog, tRNA-yW-synthesizing protein 2

Gen-ID: 55039

NCBI Accession: NP_060426

UniProt: Q53H54