2600017H02Rik antikoerper, RGD1561781 antikoerper, zgc:77242 antikoerper, transmembrane protein 88 antikoerper, transmembrane protein 88B antikoerper, transmembrane protein 88 a antikoerper, Tmem88 antikoerper, TMEM88 antikoerper, TMEM88B antikoerper, tmem88 antikoerper, tmem88a antikoerper
Hintergrund
Transmembrane protein 88 (TMEM88) is a two-transmembrane-type protein whose C-terminal tail has been shown to bind the PDZ domain of Dishevelled (Dvl), one of the key components in Wnt signaling pathways. TMEM88 attentuated the Wnt/beta-catenin signaling induced by Wnt-1 ligand in a dose-dependent manner and knockdown of TMEM88 by RNAi increased Wnt activity, suggesting that TMEM88 plays a role in regulating Wnt signaling in a context-dependent manner.Synonyms: Transmembrane protein 88