CMYA5 Antikörper (C-Term)

Produktnummer ABIN783522

Produktdetails anti-CMYA5 Antikörper

Target: CMYA5 (Cardiomyopathy Associated 5 (CMYA5))

Bindungsspezifität: C-Term

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CMYA5 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Enzyme Immunoassay (EIA)

Spezifität: This antibody detects Myospryn at C-term. SPRYD2 antibody is predicted to not cross-react with other SPRYD protein family members. At least four isoforms of SPRYD2 are known to exist.

Kreuzreaktivität (Details): Species reactivity (tested):Human, mouse, rat.

Aufreinigung: Affinity chromatography purified via peptide column

Immunogen: 18 amino acid peptide near the carboxy terminus of human SPRYD2

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS containing 0.02 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at 2 - 8 °C for up to three months or (in aliquots) at -20 °C for longer.

Details zu CMYA5

Target: CMYA5 (Cardiomyopathy Associated 5 (CMYA5))

Andere Bezeichnung: Myospryn (CMYA5 Produkte)

Hintergrund: SPRYD2, also known as Myospryn, was originally identified as the muscle-specific partner of dysbindin and as a Mef-2 target gene. It is a large scaffolding protein localized to the Z-disc/costamere region of striated muscle. SPRYD2 includes a noncanonical tripartite motif (TRIM-like) that lacks the RING domain but consists of a B-box coiled coil (BBC), fibronectin 3 (FN3) repeats, and SPRY domains. SPRYD2 interacts with desmin and calcineurin, and it has been suggested to play a role in the biogenesis of lysosome and negatively regulates slow-fiber-type transformation and skeletal muscle regeneration. SPRYD2 is dysregulated in Duchenne muscular dystrophy.Synonyms: C5orf10, CMYA5, Cardiomyopathy-associated protein 5, DTNBP2, Dystrobrevin-binding protein 2, Genethonin-3, SPRY domain-containing protein 2, SPRYD2, TRIM76, Tripartite motif-containing protein 76

Gen-ID: 202333

NCBI Accession: NP_705838

UniProt: Q8N3K9