ATG13 Antikörper (C-Term)

Produktnummer ABIN783663

Produktdetails anti-ATG13 Antikörper

Target: ATG13 (Autophagy Related 13 (ATG13))

Bindungsspezifität: C-Term

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ATG13 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA)

Kreuzreaktivität (Details): Species reactivity (tested):Human, mouse, rat

Aufreinigung: Affinity chromatography purified via peptide column

Immunogen: 15 amino acid peptide near the carboxy terminus of human ATG13

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: PBS containing 0.02 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: -20 °C

Informationen zur Lagerung: Store the antibody (in aliquots) at -20 °C.

Details zu ATG13

Target: ATG13 (Autophagy Related 13 (ATG13))

Andere Bezeichnung: KIAA0652 (ATG13 Produkte)

Synonyme: zgc:63526 antikoerper, KIAA0652 antikoerper, PARATARG8 antikoerper, 1110053A20Rik antikoerper, D2Ertd391e antikoerper, Harbi1 antikoerper, Harbi1l antikoerper, RGD1310685 antikoerper, autophagy related 13 antikoerper, ATG13 autophagy related 13 homolog (S. cerevisiae) antikoerper, ATG13 antikoerper, atg13 antikoerper, Atg13 antikoerper

Hintergrund: Autophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. It is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components. This process is negatively regulated by TOR (Target of rapamycin) through phosphorylation of autophagy protein ATG1. ATG13 forms a complex with ULK1 and ULK2, the mammalian homologs of ATG1, and with FIP200. This complex is a target of TOR phosphorylation under normal conditions, inhibition of TOR by rapamycin or leucine deprivation leads to dephosphorylation of ATG13, ULK1 and ULK2, which then leads to autophagy. Knockdown of ATG13 inhibits autophagosome formation.Synonyms: UPF0630 protein KIAA0652

Gen-ID: 9776

NCBI Accession: NP_001136145

UniProt: O75143

Pathways: PI3K-Akt Signalweg, Autophagie