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ALKBH2 Antikörper (C-Term)

ALKBH2 Reaktivität: Human, Maus, Ratte WB, EIA Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN783675
  • Target Alle ALKBH2 Antikörper anzeigen
    ALKBH2 (AlkB, Alkylation Repair Homolog 2 (ALKBH2))
    Bindungsspezifität
    • 2
    • 2
    • 1
    • 1
    • 1
    C-Term
    Reaktivität
    • 14
    • 11
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    Human, Maus, Ratte
    Wirt
    • 13
    • 1
    Kaninchen
    Klonalität
    • 13
    • 1
    Polyklonal
    Konjugat
    • 7
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser ALKBH2 Antikörper ist unkonjugiert
    Applikation
    • 6
    • 4
    • 2
    • 1
    Western Blotting (WB), Enzyme Immunoassay (EIA)
    Kreuzreaktivität (Details)
    Species reactivity (tested):Human, mouse, rat
    Aufreinigung
    Affinity chromatography purified via peptide column
    Immunogen
    15 amino acid peptide near the carboxy terminus of human ALKBH2
    Top Product
    Discover our top product ALKBH2 Primärantikörper
  • Applikationshinweise
    Optimal working dilution should be determined by the investigator.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Konzentration
    1.0 mg/mL
    Buffer
    PBS containing 0.02 % sodium azide
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Avoid repeated freezing and thawing.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store the antibody (in aliquots) at -20 °C.
  • Target
    ALKBH2 (AlkB, Alkylation Repair Homolog 2 (ALKBH2))
    Andere Bezeichnung
    ALKBH2 / ABH2 (ALKBH2 Produkte)
    Synonyme
    si:dkey-65b12.2 antikoerper, ABH2 antikoerper, 9530023G02 antikoerper, AU016977 antikoerper, Abh2 antikoerper, mABH2 antikoerper, RGD1306377 antikoerper, alkB homolog 2, alpha-ketoglutarate dependent dioxygenase antikoerper, alkB homolog 2, alpha-ketoglutarate-dependent dioxygenase antikoerper, ALKBH2 antikoerper, alkbh2 antikoerper, Alkbh2 antikoerper
    Hintergrund
    The E. coli AlkB protein protects against the cytotoxicity of methylating agents by repair of the specific DNA lesions generated in single-stranded DNA, ALKBH2 and ALKBH3 are mammalian homologs of AlkB that catalyze the removal of 1-methyladenine and 3-methylcytosine, modifications that left unchecked could lead to cancerous cells. Mutations in both ALKBH2 and ALKBH3 have been observed in pediatric brain tumors indicating that these proteins are important in the prevention of cancer formation. Like the histone demethylase JMJD1A, ALKBH2 is a non-heme iron enzyme that is inhibited by Nickel ions, suggesting that inhibition of ALKBH2 by Nickel ions may play a role in the development of cancer. Conversely, ALKBH2 mRNA and protein levels are increased glioma cells following Photofrin-mediated photodynamic therapy, an adjuvant therapy in cancer treatment, suggesting that down-regulating ALKBH2 expression in cancer cells may enhance the anti-cancer effectiveness of this treatment.Synonyms: Alkylated DNA repair protein alkB homolog 2, Alpha-ketoglutarate-dependent dioxygenase alkB homolog 2, Oxy DC1
    Gen-ID
    121642
    NCBI Accession
    NP_001001655
    UniProt
    Q6NS38
    Pathways
    DNA Reparatur
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