BANP Antikörper (Center)

Produktnummer ABIN783725

Produktdetails anti-BANP Antikörper

Target: BANP (Protein BANP (BANP))

Bindungsspezifität: Center

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser BANP Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Enzyme Immunoassay (EIA)

Spezifität: This antibody detects BANP / SMAR1 at Center.

Kreuzreaktivität (Details): Species reactivity (tested):Human, mouse, rat

Aufreinigung: Affinity chromatography purified via peptide column

Immunogen: 14 amino acid peptide near the center of human BANP

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: Antibody is supplied in PBS containing 0.02 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at 2 - 8 °C for up to three months or (in aliquots) at -20 °C for longer.

Details zu BANP

Target: BANP (Protein BANP (BANP))

Andere Bezeichnung: BANP / SMAR1 (BANP Produkte)

Synonyme: smar1 antikoerper, smarbp1 antikoerper, MGC76079 antikoerper, MGC89601 antikoerper, BEND1 antikoerper, SMAR1 antikoerper, SMARBP1 antikoerper, AA408158 antikoerper, zgc:111954 antikoerper, BTG3 associated nuclear protein antikoerper, Btg3 associated nuclear protein antikoerper, BTG3 associated nuclear protein L homeolog antikoerper, banp antikoerper, BANP antikoerper, Banp antikoerper, banp.L antikoerper

Hintergrund: BANP was initially identified as a binding protein to BTG3 in a yeast two-hybrid screen. BANP acts as a tumor suppressor by stabilizing p53 expression and leading to cell cycle arrest. p53 in turn binds to upstream elements of the BANP promoter, thereby forming a feedback loop. BANP is down-regulated in advanced stages of human breast cancer, and its overexpression in breast cancer cell lines inhibits their ability to metastasize by modulating TGF-b signaling. Furthermore, BANP can modulate NF-kB transactivation and can inhibit tumorigenesis by regulating NF-kB target genes. Recent experiments have shown that BANP can also repress HIV-1 LTR mediated transcription by tethering the LTR matrix attachment region to nuclear matrix.Synonyms: BEN domain-containing protein 1, BEND1, Btg3-associated nuclear protein, Scaffold/matrix-associated region-1-binding protein

Gen-ID: 54971

NCBI Accession: NP_001167010

UniProt: Q8N9N5