BCL2L14 Antikörper (C-Term)

Produktnummer ABIN783818

Der Kaninchen Polyklonal Anti-BCL2L14-Antikörper wurde für WB, IHC (p) und EIA validiert. Er ist geeignet, BCL2L14 in Proben von Human, Maus und Ratte zu detektieren.

Kurzübersicht für BCL2L14 Antikörper (C-Term) (ABIN783818)

Target: BCL2L14 (BCL2-Like 14 (Apoptosis Facilitator) (BCL2L14))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser BCL2L14 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Produktdetails anti-BCL2L14 Antikörper

Bindungsspezifität: C-Term

Spezifität: This antibody detects Bcl-2-like 14 at C-term.

Kreuzreaktivität (Details): Species reactivity (tested):Human, mouse, rat

Aufreinigung: Ion exchange chromatography purified

Immunogen: 15 amino acids near the C-terminus of human Bcl-G

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS containing 0.02 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at 2 - 8 °C for up to three months or (in aliquots) at -20 °C for longer.

Details zu BCL2L14

Target: BCL2L14 (BCL2-Like 14 (Apoptosis Facilitator) (BCL2L14))

Andere Bezeichnung: Bcl-2-Like 14

Hintergrund: Members in the Bcl-2 family are critical regulators of apoptosis by either inhibiting or promoting cell death. Bcl-2 homology 3 (BH3) domain is a potent death domain (reviewed in 1 and 2). BH3 domain containing pro-apoptotic proteins, including Bad, Bax, Bid, Bik, and Hrk, form a growing subclass of the Bcl-2 family. A novel BH3 domain containing protein was recently identified and designated Bcl-G (3). The mRNA of Bcl-G encodes 2 isoforms, Bcl-GL, which is widely expressed in multiple tissues, and Bcl-GS, which is only found in testis. The Bcl-GS protein is predominantly localized to cytoplasmic organelles whereas Bcl-GL was distributed throughout the cytosol. Overexpression of either protein induced apoptosis, although Bcl-GS was far more potent than Bcl-GS. Apoptosis induction was dependent on the BH3 domain and could be suppressed by co-expression with the anti-apoptotic Bcl-XL protein (3).Synonyms: Apoptosis facilitator Bcl-2-like protein 14, BCL2L14, BCLG, Bcl-G, Bcl2-L-14

Gen-ID: 79370

NCBI Accession: NP_110393

UniProt: Q9BZR8