MAPT Antikörper

Produktnummer ABIN783852

Produktdetails anti-MAPT Antikörper

Target: MAPT (Microtubule-Associated Protein tau (MAPT))

Reaktivität: Human, Ratte, Maus, Rind (Kuh), Huhn

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MAPT Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Spezifität: This antibody recognizes mainly the truncated Tau (~30 kDa) in samples from human, mouse and rat origins. Other isoforms of Tau at 35 kDa, 60 kDa and 80 kDa can also be recognized.

Kreuzreaktivität (Details): Species reactivity (tested):Human, mouse, rat, chicken, bovine

Aufreinigung: Affinity chromatography

Immunogen: Synthetic peptide surrounding amino acid 395 of rat Tau

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: Phosphate-buffered saline (PBS) containing 30 % glycerol, 0.5 % BSA, and 0.01 % thimerosal

Konservierungsmittel: Thimerosal (Merthiolate)

Vorsichtsmaßnahmen: This product contains thimerosal (merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: -20 °C

Informationen zur Lagerung: Upon receipt, store at -20 °C. For long term storage, aliquot and store at -70 °C.

Details zu MAPT

Target: MAPT (Microtubule-Associated Protein tau (MAPT))

Andere Bezeichnung: MAPT / tau (MAPT Produkte)

Synonyme: DDPAC antikoerper, FTDP-17 antikoerper, MAPTL antikoerper, MSTD antikoerper, MTBT1 antikoerper, MTBT2 antikoerper, PPND antikoerper, TAU antikoerper, AI413597 antikoerper, AW045860 antikoerper, Mtapt antikoerper, Tau antikoerper, RNPTAU antikoerper, pTau antikoerper, tau antikoerper, xtp antikoerper, MAPT antikoerper, PHF-tau antikoerper, slc6a6 antikoerper, taut antikoerper, wu:fc26e12 antikoerper, microtubule associated protein tau antikoerper, microtubule-associated protein tau antikoerper, microtubule associated protein tau S homeolog antikoerper, Microtubule-associated protein tau antikoerper, solute carrier family 6 (neurotransmitter transporter), member 6b antikoerper, MAPT antikoerper, Mapt antikoerper, mapt.S antikoerper, LOC5580230 antikoerper, CpipJ_CPIJ013260 antikoerper, tau antikoerper, slc6a6b antikoerper

Hintergrund: Tau, a microtubule-binding protein which serves to stabilize microtubules in growing axons, is found to be hyperphosphorylated in paired helical filaments (PHF), the major fibrous component of neurofibrillary lesions associated with Alzheimer's disease. Hyperphosphorylation of Tau is thought to be the critical event leading to the assembly of PHF. Six Tau protein isoforms have been identified, all of which are phosphorylated by GSK3. This presents the possibility that miscues in GSK3 signaling contribute to the onset of Alzheimer's disease.Synonyms: MAPTL, MTBT1, Microtubule-associated protein tau, Neurofibrillary tangle protein, PHF-tau, Paired helical filament-tau

Gen-ID: 4137

NCBI Accession: NP_001116538

UniProt: P10636

Pathways: MAPK Signalweg, Microtubule Dynamics, M Phase, Regulation of Cell Size