IRS1 Antikörper (pSer312)
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- Target Alle IRS1 Antikörper anzeigen
- IRS1 (Insulin Receptor Substrate 1 (IRS1))
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Bindungsspezifität
- pSer312
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Reaktivität
- Human, Ratte
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser IRS1 Antikörper ist unkonjugiert
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Applikation
- ELISA, Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
- Kreuzreaktivität
- Human, Ratte
- Homologie
- Mouse,Dog,Cow,Sheep,Pig,Horse,Rabbit
- Aufreinigung
- Purified by Protein A.
- Immunogen
- KLH conjugated synthetic phosphopeptide derived from human IRS1 around the phosphorylation site of Ser312 [AT(p-S)PA]
- Isotyp
- IgG
- Top Product
- Discover our top product IRS1 Primärantikörper
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- Applikationshinweise
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WB 1:300-5000
ELISA 1:500-1000
FCM 1:20-100
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 - Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 1 μg/μL
- Buffer
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
- Konservierungsmittel
- ProClin
- Vorsichtsmaßnahmen
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Lagerung
- 4 °C,-20 °C
- Informationen zur Lagerung
- Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
- Haltbarkeit
- 12 months
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Chicory inulin ameliorates type 2 diabetes mellitus and suppresses JNK and MAPK pathways in vivo and in vitro." in: Molecular nutrition & food research, (2017) (PubMed).
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Chicory inulin ameliorates type 2 diabetes mellitus and suppresses JNK and MAPK pathways in vivo and in vitro." in: Molecular nutrition & food research, (2017) (PubMed).
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- Target
- IRS1 (Insulin Receptor Substrate 1 (IRS1))
- Andere Bezeichnung
- IRS1 (IRS1 Produkte)
- Synonyme
- HIRS-1 antikoerper, G972R antikoerper, IRS-1 antikoerper, IRS1IRM antikoerper, irs1 antikoerper, irsu antikoerper, IRS1 antikoerper, irs-1 antikoerper, irs1-a antikoerper, insulin receptor substrate 1 antikoerper, insulin receptor substrate 2 antikoerper, insulin receptor substrate 1 S homeolog antikoerper, IRS1 antikoerper, Irs1 antikoerper, irs2 antikoerper, irs1.S antikoerper
- Hintergrund
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Synonyms: IRS-1 Ser312, p-IRS1, IRS1Ser789, HIRS 1, HIRS1, Insulin Receptor Substrate 1, IRS-1, IRS 1, IRS1, OTTHUMP00000164234, IRS1_HUMAN.
Background: Insulin receptor substrates (IRS) are responsible for several insulin related activities, such as glucose homeostasis, cell growth, cell transformation, apoptosis and insulin signal transduction. Serine/threonine phosphorylation of IRS1 has been demonstrated to be a negative regulator of insulin signaling and is responsible for its degradation, although IRS1 degradation pathways are not well understood. IRS1 has also been shown to be constitutively activated in cancers such as breast cancer, Wilm's tumors, and adrenal cortical carcinomas, thus making IRS1 phosphorylation and subsequent degradation an attractive therapeutic target. To date there have been four subtypes identified: IRS1, 2, 3 and 4, with IRS1 being widely expressed.
- Gen-ID
- 3667
- Pathways
- Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Positive Regulation of Peptide Hormone Secretion, Hormone Transport, Negative Regulation of Hormone Secretion, Response to Growth Hormone Stimulus, Carbohydrate Homeostasis, Regulation of Carbohydrate Metabolic Process
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