Piccolo Antikörper

Produktnummer ABIN863197

Produktdetails anti-Piccolo Antikörper

Target: Piccolo (PIC)

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Piccolo Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Spezifität: Detects ~550 kDa. No cross-reactivity to Bassoon.

Kreuzreaktivität: Human, Maus, Ratte

Aufreinigung: Protein A Purified

Immunogen: Recombinant Full length Protein, BC001304.1

Anwendungsinformationen

Applikationshinweise:

• WB (1:1000)
• IHC (1:400)
• optimal dilutions for assays should be determined by the user.

Kommentare:

1 μg/ml of ABIN863197 was sufficient for detection of Piccolo in 10 μg of rat brain tissue lysate by colorimetric immunoblot analysis using goat ant rabbit IgG:HRP as the secondary antibody.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: PBS pH 7.4, 50 % glycerol, 0.09 % sodium azide, Storage buffer may change when conjugated

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: -20°C

Details zu Piccolo

Target: Piccolo (PIC)

Andere Bezeichnung: Piccolo (PIC Produkte)

Hintergrund: Piccolo, also referred to as Aczonin, is a large protein which consists of an N-terminal Zn2+ finger, several piccolo-bassoon homology domains and C-terminal PDZ and C2 domains (1, 2). In general it is found together with bassoon, a related huge multi-domain protein of the CAZ (cytoskeletal matric assembled at active zones) (3). Piccolo is a scaffolding protein for proteins involved in endo- and exocytosis of synaptic vesicles. Piccolo has also been shown to interfere with clathrin medicated endocytosis by binding to the F-actin and dynamin binding protein Abp1 (2).

Gen-ID: 27445

NCBI Accession: NP_055325

UniProt: Q9Y6V0