Aquaporin 4 Antikörper (C-Term)

Produktnummer ABIN863209

Produktdetails anti-Aquaporin 4 Antikörper

Target: Aquaporin 4 (AQP4)

Bindungsspezifität: C-Term

Reaktivität: Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Aquaporin 4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunofluorescence (IF)

Spezifität: Detects ~35 kDa. May detect larger glycosylated bands ~50 kDa.

Kreuzreaktivität: Human, Maus, Ratte

Aufreinigung: Protein A Purified

Immunogen: Produced against the C-terminal peptide (Sequence N-CTKGSYMEVEDNRSQVETED) of rat aquaporin 4

Anwendungsinformationen

Applikationshinweise:

• WB (1:2000)
• IHC (1:200)
• ICC/IF (1:400)
• optimal dilutions for assays should be determined by the user.

Kommentare:

0.5 μg/ml of ABIN863209 was sufficient for detection of aquaporin 4 in 10 μg of rat kidney tissue lysate by colorimetric immunoblot analysis using Goat anti-rabbit IgG:HRP as the secondary antibody.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: PBS, 50 % glycerol, 0.09 % sodium azide, Storage buffer may change when conjugated

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: -20°C

Referenzen für anti-Aquaporin 4 Antikörper (ABIN863209)

Gatto, Amin, Deyoung, Hey, Mareci, Magin: "Ultra-High Field Diffusion MRI Reveals Early Axonal Pathology in Spinal Cord of ALS mice." in: Translational neurodegeneration, Vol. 7, pp. 20, (2018) (PubMed).

Details zu Aquaporin 4

Target: Aquaporin 4 (AQP4)

Andere Bezeichnung: Aquaporin 4 (AQP4 Produkte)

Synonyme: zgc:100922 antikoerper, si:ch211-192k9.1 antikoerper, AQP4 antikoerper, LOC100232616 antikoerper, HMIWC2 antikoerper, MIWC antikoerper, WCH4 antikoerper, AQP-4 antikoerper, AQP4.M23 antikoerper, MIWC2 antikoerper, Miwc antikoerper, aquaporin-4 antikoerper, aquaporin 4 antikoerper, aquaporin 4 L homeolog antikoerper, aqp4 antikoerper, AQP4 antikoerper, aqp4.L antikoerper, Aqp4 antikoerper

Hintergrund: Aquaporins selectively conduct water molecules in and out of the cell, while preventing the passage of ions and other solutes. Known as water channels, they are integral membrane pore proteins (1, 2). Aquaporin 4 is constitutively expressed in the basolateral cell membrane of principal collecting duct cells in the kidney and provide a pathway for water to exit these cells (3). It is also expressed in astrocytes and is up regulated by direct insult to the CNS (4). Aquaporin 4 has been proposed as the primary autoimmune target in neuromyelitis optica ( 5, 6).

Gen-ID: 25293

NCBI Accession: NP_036957

UniProt: P47863

Pathways: Sensory Perception of Sound