PKM1 (AA 399-403) Antikörper
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- Target
- PKM1
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Bindungsspezifität
- AA 399-403
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Reaktivität
- Human, Maus
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Unkonjugiert
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Applikation
- Western Blotting (WB)
- Spezifität
- The antibody detects endogenous levels of total PKM1 protein.
- Aufreinigung
- Affinity purified
- Immunogen
- Peptide sequence around AA 399-403 (V-R-A-S-S) derived from Human PKM1. Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates.
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- Applikationshinweise
- Western blotting: 1:1000
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 1 mg/mL
- Buffer
- Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- 4 °C/-20 °C
- Informationen zur Lagerung
- Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.
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- Target
- PKM1
- Hintergrund
- Glycolytic enzyme that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP. Stimulates POU5F1-mediated transcriptional activation. Plays a general role in caspase independent cell death of tumor cells. The ratio betwween the highly active tetrameric form and nearly inactive dimeric form determines whether glucose carbons are channeled to biosynthetic processes or used for glycolytic ATP production. The transition between the 2 forms contributes to the control of glycolysis and is important for tumor cell proliferation and survival.
- Molekulargewicht
- 60 kDa
- Gen-ID
- 5315
- NCBI Accession
- NP_872270
- UniProt
- P14618
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