SRRT Antikörper (AA 721-800)

Produktnummer ABIN872317

Produktdetails anti-SRRT Antikörper

Target: SRRT (Serrate RNA Effector Molecule Homolog (SRRT))

Bindungsspezifität: AA 721-800

Reaktivität: Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SRRT Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc))

Kreuzreaktivität: Ratte

Homologie: Human,Mouse,Dog,Cow,Pig,Horse

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human ARS2

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Details zu SRRT

Target: SRRT (Serrate RNA Effector Molecule Homolog (SRRT))

Andere Bezeichnung: ARS2 (SRRT Produkte)

Synonyme: CG7843 antikoerper, Dmel\\CG7843 antikoerper, anon-WO0118547.166 antikoerper, ars2 antikoerper, ars2-A antikoerper, serrate antikoerper, ARS2 antikoerper, ASR2 antikoerper, 2810019G02Rik antikoerper, ASR2A antikoerper, ASR2B antikoerper, ASR2C antikoerper, ASR2D antikoerper, Ars2 antikoerper, Asr2 antikoerper, MGC92060 antikoerper, CHUNP6881 antikoerper, zgc:92060 antikoerper, Arsenic resistance protein 2 antikoerper, serrate, RNA effector molecule S homeolog antikoerper, serrate, RNA effector molecule antikoerper, serrate RNA effector molecule homolog (Arabidopsis) antikoerper, Ars2 antikoerper, srrt.S antikoerper, SRRT antikoerper, Srrt antikoerper, srrt antikoerper

Hintergrund:

Synonyms: ARS2 protein, Arsenate resistance protein ARS2, Arsenite resistance protein 2, Arsenite resistance protein, ASR2, MGC126427, Serrate, Serrate RNA effector molecule homolog Arabidopsis, Serrate RNA effector molecule homolog, SRRT, SRRT_HUMAN.

Background: ARS2(Arsenite resistance protein 2) confers arsenite resistance. The protein belongs to the ARS2 family. Arsenic is a human carcinogen whose mechanism of action is unknown. The arsenite acts as a comutagen by interfering with DNA repair. Two genes, ASR1(Arsenite resistance protein 1) and ASR2 (Arsenite resistance protein 2), confer arsenite resistance to arsenite-sensitive cells. ASR1 shows almost complete homology with the rat fau gene, a tumor suppressor gene which contains a ubiquitin like region fused to S30 ribosomal protein. Arsenite inhibits ubiquitin dependent proteolysis. The tumor suppressor fau gene product or some other aspect of the ubiquitin system may be a target for arsenic toxicity and that disruption of the ubiquitin system may contribute to the genotoxicity and carcinogenicity of arsenite.

Gen-ID: 51593

Pathways: Notch Signalweg, Stem Cell Maintenance