FAM33A Antikörper (AA 2-88)

Produktnummer ABIN872464

Produktdetails anti-FAM33A Antikörper

Target: FAM33A (Spindle and Kinetochore-Associated Protein 2 (FAM33A))

Bindungsspezifität: AA 2-88

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser FAM33A Antikörper ist unkonjugiert

Applikation: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Homologie: Human,Mouse,Rat,Dog,Cow,Pig,Horse,Rabbit

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human SKA2

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Details zu FAM33A

Target: FAM33A (Spindle and Kinetochore-Associated Protein 2 (FAM33A))

Andere Bezeichnung: SKA2 (FAM33A Produkte)

Synonyme: FAM33A antikoerper, 1110001A07Rik antikoerper, C78640 antikoerper, Fam33a antikoerper, RGD1307084 antikoerper, fam33a antikoerper, spindle and kinetochore associated complex subunit 2 antikoerper, Spindle and kinetochore-associated protein 2 antikoerper, SKA2 antikoerper, Ska2 antikoerper, ska2 antikoerper

Hintergrund:

Synonyms: FAM33A, Family with sequence similarity 33, member A, FLJ12758, MGC110975, Protein FAM33A, SKA 2, SKA2, SKA2_HUMAN, Spindle and kinetochore associated complex subunit 2, Spindle and kinetochore associated protein 2, Spindle and kinetochore-associated protein 2, Spindle and KT kinetochore associated 2, Spindle and KT associated 2.

Background: Ska2 (spindle and kinetochore associated complex subunit 2), also known as FAM33A, is a 121 amino acid component of the Ska1 complex, a microtubule-binding subcomplex of the outer kinetochore that is critical for proper chromosome segregation. The Ska1 complex is a component of the kinetochore-microtubule interface and directly associates with microtubules as oligomeric assemblies. Localized to the outer kinetochore and spindle microtubules during cell proliferation, Ska2 is essential for spindle checkpoint silencing and exit from mitosis. Downregulation of Ska2 leads to delayed recruitment of MAD2, a component of the mitotic spindle checkpoint, to several kinetochores resulting in occasional loss of individual chromosomes from the metaphase plate. Ska2 is encoded by a gene located on human chromosome 17, which comprises over 2.5 % of the human genome and encodes over 1,200 genes.

Pathways: M Phase