Separase Antikörper (AA 1851-1950)

Produktnummer ABIN872482

Produktdetails anti-Separase Antikörper

Target: Separase (ESPL1) (Extra Spindle Poles Like 1 (ESPL1))

Bindungsspezifität: AA 1851-1950

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Separase Antikörper ist unkonjugiert

Applikation: ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunocytochemistry (ICC)

Homologie: Human,Mouse,Rat,Dog,Cow,Pig,Horse,Rabbit

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Separase

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Details zu Separase

Target: Separase (ESPL1) (Extra Spindle Poles Like 1 (ESPL1))

Andere Bezeichnung: Separase (ESPL1 Produkte)

Synonyme: ESP1 antikoerper, SEPA antikoerper, mp:zf637-3-001691 antikoerper, AL024103 antikoerper, AU045071 antikoerper, Cerp antikoerper, PRCE antikoerper, SSE antikoerper, extra spindle pole bodies like 1, separase antikoerper, extra spindle poles like 1 antikoerper, extra spindle pole bodies 1, separase antikoerper, ESPL1 antikoerper, espl1 antikoerper, Espl1 antikoerper

Hintergrund:

Synonyms: Caspase like protein ESPL1, ESP 1, ESP1, ESP-1, ESPL 1, ESPL1, ESPL-1, Extra spindle poles like 1, Extra spindle poles like 1 protein, Separin, Similar to fission yeast cut1and gene, SSE, Separase, ESPL1_HUMAN.

Background: Stable cohesion between sister chromatids before anaphase and their timely separation during anaphase are critical for chromosome inheritance. In vertebrates, sister chromatid cohesion is released in 2 steps via distinct mechanisms. The first step involves phosphorylation of STAG1 (MIM 604358) or STAG2 (MIM 300826) in the cohesin complex. The second step involves cleavage of the cohesin subunit SCC1 (RAD21, MIM 606462) by ESPL1, or separase, which initiates the final separation of sister chromatids (Sun et al., 2009 [PubMed 19345191]).[supplied by OMIM, Nov 2010].

Gen-ID: 9700