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PIDD Antikörper (AA 551-650)

PIDD Reaktivität: Ratte ELISA, IF (cc), IF (p), IHC (p), IHC (fro) Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN873247
  • Target Alle PIDD Antikörper anzeigen
    PIDD (P53-Induced Death Domain Protein (PIDD))
    Bindungsspezifität
    • 14
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 551-650
    Reaktivität
    • 20
    • 19
    • 8
    • 2
    • 1
    • 1
    • 1
    • 1
    Ratte
    Wirt
    • 33
    • 3
    Kaninchen
    Klonalität
    • 33
    • 3
    Polyklonal
    Konjugat
    • 15
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser PIDD Antikörper ist unkonjugiert
    Applikation
    • 14
    • 12
    • 12
    • 7
    • 5
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
    Kreuzreaktivität
    Ratte
    Homologie
    Human,Mouse
    Aufreinigung
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human LRDD/PIDD
    Isotyp
    IgG
    Top Product
    Discover our top product PIDD Primärantikörper
  • Applikationshinweise
    ELISA 1:500-1000
    IHC-P 1:200-400
    IHC-F 1:100-500
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 μg/μL
    Buffer
    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
    Konservierungsmittel
    ProClin
    Vorsichtsmaßnahmen
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    Haltbarkeit
    12 months
  • Target
    PIDD (P53-Induced Death Domain Protein (PIDD))
    Andere Bezeichnung
    LRDD (PIDD Produkte)
    Synonyme
    1200011D09Rik antikoerper, AU042446 antikoerper, Pidd antikoerper, LRDD antikoerper, Lrdd antikoerper, p53 induced death domain protein 1 antikoerper, p53-induced death domain protein 1 antikoerper, Pidd1 antikoerper, PIDD1 antikoerper
    Hintergrund

    Synonyms: Leucine rich repeats and death domain containing, Leucine-rich repeats and death domain containing, MGC16925, p53-induced protein with a death domain, PIDD, DKFZp434D229, PIDD_HUMAN.

    Background: The death domain (DD) containing protein PIDD is a p53 target gene in an erythroleukemia cell line that undergoes G1 phase arrest and subsequent apoptosis after p53 expression. Independently, PIDD was also described as a DD-containing protein with unknown function. The N-terminal region of PIDD contains seven leucine-rich repeats (LRRs), a protein interaction motif found in various proteins with diverse functions, followed by two ZU-5 domains and a C-terminal DD. PIDD forms a complex with caspase-2 and the adaptor protein RAIDD. Increased PIDD expression results in spontaneous activation of caspase-2 and sensitization to apoptosis by genotoxic stimuli, via interaction with caspase-2 and CRADD/RAIDD. PIDD also promotes apoptosis downstream of p53 as component of the DNA damage/stress response pathway that connects p53/TP53 to apoptosis. PIDD has also been shown to interact with NEMO/IKBKG and RIP1 and enhance sumoylation and ubiquitination of NEMO/IKBKG, an important component for activation of the transcription factor NF-kappa-B.

    Pathways
    p53 Signalweg, Caspase Kaskade in der Apoptose, Positive Regulation of Endopeptidase Activity
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