CBL Antikörper (pTyr700) (AbBy Fluor® 555)
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- Target Alle CBL Antikörper anzeigen
- CBL (Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence (CBL))
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Bindungsspezifität
- pTyr700
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Reaktivität
- Human, Ratte
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser CBL Antikörper ist konjugiert mit AbBy Fluor® 555
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Applikation
- Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
- Kreuzreaktivität
- Human, Ratte
- Homologie
- Mouse,Dog,Cow,Pig,Horse
- Aufreinigung
- Purified by Protein A.
- Immunogen
- KLH conjugated synthetic phosphopeptide derived from human C CBL around the phosphorylation site of Tyr700
- Isotyp
- IgG
- Top Product
- Discover our top product CBL Primärantikörper
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- Applikationshinweise
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IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 - Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 1 μg/μL
- Buffer
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
- Konservierungsmittel
- ProClin
- Vorsichtsmaßnahmen
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Haltbarkeit
- 12 months
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- Target
- CBL (Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence (CBL))
- Andere Bezeichnung
- CBL2 (CBL Produkte)
- Synonyme
- 4732447J05Rik antikoerper, Cbl-2 antikoerper, c-Cbl antikoerper, cbl antikoerper, C-CBL antikoerper, CBL2 antikoerper, FRA11B antikoerper, NSLL antikoerper, RNF55 antikoerper, c-cbl-like antikoerper, RGD1561386 antikoerper, Casitas B-lineage lymphoma antikoerper, Cbl proto-oncogene antikoerper, Cbl antikoerper, CBL antikoerper
- Hintergrund
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Synonyms: C CBL Tyr700, CBL2 Tyr700, CBL2 Y700, p-CBL2 Tyr700, p-CBL2 Y700, C CBL, Cas-Br-M murine ecotropic retroviral transforming sequence, Casitas B lineage lymphoma proto oncogene, CBL 2,E3 ubiquitin protein ligase CBL, Oncogene CBL2, Proto oncogene c CBL, RGD1561386, RING finger protein 55, RNF55v Signal transduction protein CBL, 4732447J05Rik, CBL_HUMAN.
Background: This gene is a proto-oncogene that encodes a RING finger E3 ubiquitin ligase. The encoded protein is one of the enzymes required for targeting substrates for degradation by the proteasome. This protein mediates the transfer of ubiquitin from ubiquitin conjugating enzymes (E2) to specific substrates. This protein also contains an N-terminal phosphotyrosine binding domain that allows it to interact with numerous tyrosine-phosphorylated substrates and target them for proteasome degradation. As such it functions as a negative regulator of many signal transduction pathways. This gene has been found to be mutated or translocated in many cancers including acute myeloid leukaemia. Mutations in this gene are also the cause of Noonan syndrome-like disorder. [provided by RefSeq, Mar 2012]
- Gen-ID
- 867
- Pathways
- T-Zell Rezeptor Signalweg, Interferon-gamma Pathway, EGFR Signaling Pathway, EGFR Downregulation, VEGFR1 Specific Signals
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