CDC14B Antikörper (AA 65-160) (Cy5)

Produktnummer ABIN889447

Produktdetails anti-CDC14B Antikörper (Cy5)

Target: CDC14B (CDC14 Cell Division Cycle 14B (CDC14B))

Bindungsspezifität: AA 65-160

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CDC14B Antikörper ist konjugiert mit Cy5

Applikation: Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Kreuzreaktivität: Human, Maus, Ratte

Homologie: Rabbit

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human CDC14B

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Details zu CDC14B

Target: CDC14B (CDC14 Cell Division Cycle 14B (CDC14B))

Andere Bezeichnung: CDC14B (CDC14B Produkte)

Synonyme: CDC14B antikoerper, 2810432N10Rik antikoerper, A530086E13Rik antikoerper, AA472821 antikoerper, CDC14B3 antikoerper, Cdc14B1 antikoerper, Cdc14B2 antikoerper, hCDC14B antikoerper, Dual specificity protein phosphatase CDC14B antikoerper, dual specificity protein phosphatase CDC14B antikoerper, cell division cycle 14B antikoerper, CDC14 cell division cycle 14B antikoerper, Bm1_19115 antikoerper, LOAG_10083 antikoerper, CDC14B antikoerper, cdc14b antikoerper, Cdc14b antikoerper

Hintergrund:

Synonyms: CDC14B3, Cdc14B1, Cdc14B2, hCDC14B, Dual specificity protein phosphatase CDC14B, CDC14 cell division cycle 14 homolog B, CDC14B

Background: Dual-specificity phosphatase involved in DNA damage response. Essential regulator of the G2 DNA damage checkpoint: following DNA damage, translocates to the nucleus and dephosphorylates FZR1/CDH1, a key activator of the anaphase promoting complex/cyclosome (APC/C). Dephosphorylates SIRT2 around early anaphase. Dephosphorylation of FZR1/CDH1 activates the APC/C, leading to the ubiquitination of PLK1, preventing entry into mitosis. Preferentially dephosphorylates proteins modified by proline-directed kinases.

Gen-ID: 8555

UniProt: O60729