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CPB2 Antikörper (AA 131-230) (Biotin)

CPB2 Reaktivität: Human ELISA, IHC (p), IHC (fro) Wirt: Kaninchen Polyclonal Biotin
Produktnummer ABIN892100
  • Target Alle CPB2 Antikörper anzeigen
    CPB2 (Carboxypeptidase B2 (Plasma) (CPB2))
    Bindungsspezifität
    • 14
    • 6
    • 3
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 131-230
    Reaktivität
    • 53
    • 23
    • 11
    • 2
    • 1
    • 1
    • 1
    • 1
    Human
    Wirt
    • 57
    • 7
    • 4
    Kaninchen
    Klonalität
    • 62
    • 6
    Polyklonal
    Konjugat
    • 32
    • 7
    • 7
    • 5
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser CPB2 Antikörper ist konjugiert mit Biotin
    Applikation
    • 38
    • 20
    • 13
    • 13
    • 13
    • 8
    • 6
    • 4
    • 4
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
    Kreuzreaktivität
    Human
    Homologie
    Mouse,Rat,Dog,Cow,Horse
    Aufreinigung
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human CPB2
    Isotyp
    IgG
    Top Product
    Discover our top product CPB2 Primärantikörper
  • Applikationshinweise
    IHC-P 1:200-400
    IHC-F 1:100-500
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Konservierungsmittel
    ProClin
    Vorsichtsmaßnahmen
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20°C for 12 months.
    Haltbarkeit
    12 months
  • Target
    CPB2 (Carboxypeptidase B2 (Plasma) (CPB2))
    Andere Bezeichnung
    CPB2 (CPB2 Produkte)
    Synonyme
    CPU antikoerper, PCPB antikoerper, TAFI antikoerper, 1110032P04Rik antikoerper, 4930405E17Rik antikoerper, AI255929 antikoerper, CPR antikoerper, Cpu antikoerper, pCPB antikoerper, zgc:112493 antikoerper, carboxypeptidase B2 antikoerper, carboxypeptidase B2 (plasma) antikoerper, CPB2 antikoerper, Cpb2 antikoerper, cpb2 antikoerper
    Hintergrund

    Synonyms: Carboxypeptidase B like protein, Carboxypeptidase U, CarboxypeptidaseB2, Carboxypeptidase B2, CarboxypeptidaseU, CP B2, CPB 2, CPB2, CPU, PCPB, Plasma carboxypeptidase B, Plasma carboxypeptidase B2, Procarboxypeptidase B, Procarboxypeptidase R, Procarboxypeptidase U, TAFI, Thrombin activable fibrinolysis inhibitor, Thrombin activatable fibrinolysis inhibitor.

    Background: This protein belongs to a family of Zn-containing metallocarboxypeptidases specific to C-terminal lysine and arginine residues. It circulates in plasma as a zymogen with molecular weight of 55 kDa (401 amino acid residues, pI 5.0). Being activated by thrombin-thrombomodulin complex during blood coagulation, it exerts carboxypeptidase activity. Activated carboxypeptidase B2 removes C-terminal lysine residues from fibrin, which is necessary for plasminogen binding to fibrin. This prevents plasminogen from activation into plasmin and retards the lysis of a fibrin clot. The concentration in plasma of healthy people is 5-10 μg/mL. High plasma levels were found in patients with stable angina pectoris and angiographically verified coronary artery disease. Elevated concentration in blood is considered as a risk factor for venous thrombosis. A deficiency might contribute to the severity of bleeding disorders in hemophilias A and B, and decreased levels are found in chronic liver disease.

    Gen-ID
    1361
    Pathways
    Regulation of Actin Filament Polymerization, Carbohydrate Homeostasis
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