Deltex Homolog 1 Antikörper (AA 351-450) (AbBy Fluor® 555)
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- Target Alle Deltex Homolog 1 (DTX1) Antikörper anzeigen
- Deltex Homolog 1 (DTX1) (E3 Ubiquitin-protein ligase DTX1 (DTX1))
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Bindungsspezifität
- AA 351-450
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Reaktivität
- Human, Maus, Ratte
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser Deltex Homolog 1 Antikörper ist konjugiert mit AbBy Fluor® 555
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Applikation
- Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
- Kreuzreaktivität
- Human, Maus, Ratte
- Homologie
- Cow
- Aufreinigung
- Purified by Protein A.
- Immunogen
- KLH conjugated synthetic peptide derived from human Deltex-1
- Isotyp
- IgG
- Top Product
- Discover our top product DTX1 Primärantikörper
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- Applikationshinweise
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IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 - Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 1 μg/μL
- Buffer
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
- Konservierungsmittel
- ProClin
- Vorsichtsmaßnahmen
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Haltbarkeit
- 12 months
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- Target
- Deltex Homolog 1 (DTX1) (E3 Ubiquitin-protein ligase DTX1 (DTX1))
- Andere Bezeichnung
- Deltex 1 (DTX1 Produkte)
- Synonyme
- hDx-1 antikoerper, Fxit1 antikoerper, mKIAA4160 antikoerper, deltex antikoerper, dtx antikoerper, xdtx1 antikoerper, deltex E3 ubiquitin ligase 1 antikoerper, deltex homolog 1 (Drosophila) antikoerper, deltex 1, E3 ubiquitin ligase antikoerper, deltex 1 L homeolog antikoerper, deltex 1 S homeolog antikoerper, DTX1 antikoerper, dtx1 antikoerper, Dtx1 antikoerper, dtx1.L antikoerper, dtx1.S antikoerper
- Hintergrund
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Synonyms: hDx-1, E3 ubiquitin-protein ligase DTX1, Protein deltex-1, Deltex1, hDTX1, DTX1
Background: Functions as a ubiquitin ligase protein in vivo, mediating ubiquitination and promoting degradation of MEKK1, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity (By similarity). Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Mainly acts as a positive regulator of Notch, but it also acts as a negative regulator, depending on the developmental and cell context. Mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. Involved in neurogenesis, lymphogenesis and myogenesis, and may also be involved in MZB (Marginal zone B) cell differentiation. Promotes B-cell development at the expense of T-cell development, suggesting that it can antagonize NOTCH1.
- Gen-ID
- 1840
- UniProt
- Q86Y01
- Pathways
- Notch Signalweg
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