KLHL13 Antikörper (AA 351-450) (Biotin)

Produktnummer ABIN903888

Produktdetails anti-KLHL13 Antikörper (Biotin)

Target: KLHL13 (Kelch-Like 13 (KLHL13))

Bindungsspezifität: AA 351-450

Reaktivität: Zebrafisch (Danio rerio)

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser KLHL13 Antikörper ist konjugiert mit Biotin

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Kreuzreaktivität: Zebrafisch (Danio rerio)

Homologie: Human,Mouse,Rat,Dog,Cow,Sheep,Pig,Horse,Chicken,Rabbit

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human KLHL13

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C for 12 months.

Haltbarkeit: 12 months

Details zu KLHL13

Target: KLHL13 (Kelch-Like 13 (KLHL13))

Andere Bezeichnung: KLHL13 (KLHL13 Produkte)

Synonyme: 1200009K10Rik antikoerper, AI451128 antikoerper, Bklhd2 antikoerper, D130072F20Rik antikoerper, mKIAA1309 antikoerper, BKLHD2 antikoerper, Kelch-like protein 13 antikoerper, kelch-like 13 antikoerper, kelch like family member 13 antikoerper, kelch like family member 9 antikoerper, kelch-like family member 13 antikoerper, klh13 antikoerper, Klhl13 antikoerper, KLHL13 antikoerper, KLHL9 antikoerper

Hintergrund:

Synonyms: Kelch-like protein 13, BTB and kelch domain-containing protein 2, KLH13_HUMAN.

Background: KLHL13 (kelch like 13), also known as BKLHD2 (BTB and kelch domain containing protein 2), is a 604 amino acid protein that contains six Kelch repeats and one BTB/POZ domain. Expressed predominantly in brain, KLHL13 is believed to play a role in protein ubiquitination and may function as a substrate specific adapter of an E3 ubiquitin protein ligase complex. E3 ligases accept a ubiquitin residue from an E2 ubiquitin conjugating enzyme and immediately transfer that residue to a protein that is targeted for degradation. Specifically, KLHL13 interacts with KLHL9 and CUL3, a member of the cullin family of mediators that participate in the selective targeting of proteins for ubiquitin mediated proteolysis. Via its BTB and C terminal Kelch (BACK) motif, KLHL13 is thought to play a role in spatially orientating substrates in the CUL3 ligase.

Gen-ID: 90293