Menin Antikörper (AA 501-615) (AbBy Fluor® 555)
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- Target Alle Menin (MEN1) Antikörper anzeigen
- Menin (MEN1) (Multiple Endocrine Neoplasia 1 (MEN1))
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Bindungsspezifität
- AA 501-615
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Reaktivität
- Human, Maus, Ratte
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser Menin Antikörper ist konjugiert mit AbBy Fluor® 555
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Applikation
- Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
- Kreuzreaktivität
- Human, Maus, Ratte
- Homologie
- Dog,Cow,Pig
- Aufreinigung
- Purified by Protein A.
- Immunogen
- KLH conjugated synthetic peptide derived from human Menin
- Isotyp
- IgG
- Top Product
- Discover our top product MEN1 Primärantikörper
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- Applikationshinweise
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IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 - Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 1 μg/μL
- Buffer
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
- Konservierungsmittel
- ProClin
- Vorsichtsmaßnahmen
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Haltbarkeit
- 12 months
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- Target
- Menin (MEN1) (Multiple Endocrine Neoplasia 1 (MEN1))
- Andere Bezeichnung
- Menin (MEN1 Produkte)
- Synonyme
- MEAI antikoerper, SCG2 antikoerper, menin antikoerper, meai antikoerper, scg2 antikoerper, AW045611 antikoerper, menin 1 antikoerper, menin 1 L homeolog antikoerper, multiple endocrine neoplasia I antikoerper, multiple endocrine neoplasia 1 antikoerper, MEN1 antikoerper, men1 antikoerper, men1.L antikoerper, Men1 antikoerper
- Hintergrund
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Synonyms: MEAI, SCG2, Menin, MEN1
Background: Essential component of a MLL/SET1 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3 (H3K4). Functions as a transcriptional regulator. Binds to the TERT promoter and represses telomerase expression. Plays a role in TGFB1-mediated inhibition of cell-proliferation, possibly regulating SMAD3 transcriptional activity. Represses JUND-mediated transcriptional activation on AP1 sites, as well as that mediated by NFKB subunit RELA. Positively regulates HOXC8 and HOXC6 gene expression. May be involved in normal hematopoiesis through the activation of HOXA9 expression (By similarity). May be involved in DNA repair.
- Gen-ID
- 4221
- UniProt
- O00255
- Pathways
- Chromatin Binding, Positive Regulation of Endopeptidase Activity
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