NLRP4 Antikörper (AA 351-450) (HRP)
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- Target Alle NLRP4 Antikörper anzeigen
- NLRP4 (NLR Family, Pyrin Domain Containing 4 (NLRP4))
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Bindungsspezifität
- AA 351-450
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Reaktivität
- Human, Ratte
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser NLRP4 Antikörper ist konjugiert mit HRP
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Applikation
- ELISA, Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- Spezifität
- This antibody will detect multiple forms of NALP4, including the A, C and E Mouse variants.
- Kreuzreaktivität
- Human, Ratte
- Homologie
- Mouse,Pig,Horse
- Aufreinigung
- Purified by Protein A.
- Immunogen
- KLH conjugated synthetic peptide derived from human NALP4
- Isotyp
- IgG
- Top Product
- Discover our top product NLRP4 Primärantikörper
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- Applikationshinweise
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IHC-P 1:200-400
IHC-F 1:100-500 - Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 1 μg/μL
- Buffer
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
- Konservierungsmittel
- ProClin
- Vorsichtsmaßnahmen
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Handhabung
- Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Haltbarkeit
- 12 months
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- Target
- NLRP4 (NLR Family, Pyrin Domain Containing 4 (NLRP4))
- Andere Bezeichnung
- NALP4 (NLRP4 Produkte)
- Synonyme
- CLR19.5 antikoerper, CT58 antikoerper, NALP4 antikoerper, PAN2 antikoerper, PYPAF4 antikoerper, RNH2 antikoerper, Nalp4 antikoerper, Nlrp4e antikoerper, RGD1563529 antikoerper, NLR family pyrin domain containing 4 antikoerper, NLR family, pyrin domain containing 4 antikoerper, NLRP4 antikoerper, Nlrp4 antikoerper
- Hintergrund
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Synonyms: NACHT, LRR and PYD domains-containing protein 4, Cancer/testis antigen 58, CT58, PAAD and NACHT-containing protein 2, PAN2, PYRIN and NACHT-containing protein 2, PYRIN-containing APAF1-like protein 4, PYPAF4, Ribonuclease inhibitor 2, NLRP4, NALP4, RNH2
Background: May be involved in inflammation and recognition of cytosolic pathogen-associated molecular patterns (PAMPs) not intercepted by membrane-bound receptors. Acts as a negative regulator of the type I interferon signaling pathway by serving as an adapter to promote DTX4-mediated ubiquitination of activated TBK1, and its subsequent degradation. Suppresses NF-kappaB induction by the cytokines TNFA and IL1B, suggesting that it operates at a point of convergence in these two cytokine signaling pathways.
- Gen-ID
- 147945
- UniProt
- Q96MN2
- Pathways
- Inflammasome
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