PARP3 Antikörper (AA 301-400) (Biotin)

Produktnummer ABIN910116

Produktdetails anti-PARP3 Antikörper (Biotin)

Target: PARP3 (Poly (ADP-Ribose) Polymerase Family, Member 3 (PARP3))

Bindungsspezifität: AA 301-400

Reaktivität: Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PARP3 Antikörper ist konjugiert mit Biotin

Applikation: ELISA, Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Kreuzreaktivität: Maus

Homologie: Human,Rat,Horse,Rabbit

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human PARP3

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C for 12 months.

Haltbarkeit: 12 months

Details zu PARP3

Target: PARP3 (Poly (ADP-Ribose) Polymerase Family, Member 3 (PARP3))

Andere Bezeichnung: PARP3 (PARP3 Produkte)

Synonyme: ADPRT-3 antikoerper, PARP-3 antikoerper, PM38 antikoerper, Adprtl3 antikoerper, fj17c06 antikoerper, wu:fj17c06 antikoerper, zgc:66157 antikoerper, PARP3 antikoerper, parp3 antikoerper, ADPRT3 antikoerper, ADPRTL2 antikoerper, ADPRTL3 antikoerper, ARTD3 antikoerper, IRT1 antikoerper, PADPRT-3 antikoerper, A930002C11Rik antikoerper, AW990611 antikoerper, Adprt3 antikoerper, pADPRT-3 antikoerper, seed maturation protein PM38 antikoerper, poly (ADP-ribose) polymerase family, member 3 antikoerper, poly(ADP-ribose) polymerase family member 3 antikoerper, poly(ADP-ribose) polymerase family member 3 L homeolog antikoerper, PARP3 antikoerper, parp3 antikoerper, parp3.L antikoerper, Parp3 antikoerper

Hintergrund:

Synonyms: hPARP3, IRT1, NAD+ ADP ribosyltransferase 3, pADPRT 3, Poly[ADP ribose] synthetase 3, ADP ribosyltransferase NAD+, poly ADP ribose, ADPRT-3, ADPRT3, ADPRTL2, ADPRTL3, hPARP 3, hPARP-3, IRT 1, IRT1, NAD+ ADP-ribosyltransferase 3, NAD+ ADP ribosyltransferase 3, pADPRT-3, pADPRT3, PARP 3, PARP-3, PARP3, Poly ADP ribose polymerase family, member 3, Poly ADP ribose synthetase 3, Poly [ADP-ribose] polymerase 3, Poly[ADP-ribose] synthase 3.

Background: Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. May link the DNA damage surveillance network to the mitotic fidelity checkpoint. Negatively influences the G1/S cell cycle progression without interfering with centrosome duplication. Binds DNA. May be involved in the regulation of PRC2 and PRC3 complex-dependent gene silencing.Tissue specificity: Widely expressed, the highest levels are in the kidney, skeletal muscle, liver, heart and spleen, also detected in pancreas, lung, placenta, brain, leukocytes, colon, small intestine, ovary, testis, prostate and thymus.

Gen-ID: 10039