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PNPT1 Antikörper (AA 551-650) (AbBy Fluor® 350)

PNPT1 Reaktivität: Ratte WB, IF (cc), IF (p) Wirt: Kaninchen Polyclonal AbBy Fluor® 350
Produktnummer ABIN911617
  • Target Alle PNPT1 Antikörper anzeigen
    PNPT1 (Polyribonucleotide Nucleotidyltransferase 1 (PNPT1))
    Bindungsspezifität
    • 14
    • 7
    • 6
    • 6
    • 6
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 551-650
    Reaktivität
    • 42
    • 22
    • 18
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    Ratte
    Wirt
    • 55
    • 3
    Kaninchen
    Klonalität
    • 57
    • 1
    Polyklonal
    Konjugat
    • 27
    • 5
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser PNPT1 Antikörper ist konjugiert mit AbBy Fluor® 350
    Applikation
    • 49
    • 21
    • 12
    • 12
    • 11
    • 9
    • 8
    • 8
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
    Kreuzreaktivität
    Ratte
    Homologie
    Human,Mouse,Dog,Cow,Sheep,Horse
    Aufreinigung
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human PNPT1
    Isotyp
    IgG
    Top Product
    Discover our top product PNPT1 Primärantikörper
  • Applikationshinweise
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Konservierungsmittel
    ProClin
    Vorsichtsmaßnahmen
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    Haltbarkeit
    12 months
  • Target
    PNPT1 (Polyribonucleotide Nucleotidyltransferase 1 (PNPT1))
    Andere Bezeichnung
    PNPT1 (PNPT1 Produkte)
    Synonyme
    COXPD13 antikoerper, DFNB70 antikoerper, OLD35 antikoerper, PNPASE antikoerper, old-35 antikoerper, 1200003F12Rik antikoerper, Old35 antikoerper, PNPase antikoerper, Pnptl1 antikoerper, polyribonucleotide nucleotidyltransferase 1, mitochondrial antikoerper, polyribonucleotide nucleotidyltransferase 1 antikoerper, CpipJ_CPIJ005886 antikoerper, PNPT1 antikoerper, Pnpt1 antikoerper
    Hintergrund

    Synonyms: OLD35, DFNB70, PNPASE, old-35, COXPD13, Polyribonucleotide nucleotidyltransferase 1, mitochondrial, 3'-5' RNA exonuclease OLD35, PNPase old-35, Polynucleotide phosphorylase 1, PNPase 1, Polynucleotide phosphorylase-like protein, PNPT1

    Background: RNA-binding protein implicated in numerous RNA metabolic processes. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'-to-5' direction. Mitochondrial intermembrane factor with RNA-processing exoribonulease activity. Component of the mitochondrial degradosome (mtEXO) complex, that degrades 3' overhang double-stranded RNA with a 3'-to-5' directionality in an ATP-dependent manner. Required for correct processing and polyadenylation of mitochondrial mRNAs. Plays a role as a cytoplasmic RNA import factor that mediates the translocation of small RNA components, like the 5S RNA, the RNA subunit of ribonuclease P and the mitochondrial RNA-processing (MRP) RNA, into the mitochondrial matrix. Plays a role in mitochondrial morphogenesis and respiration, regulates the expression of the electron transport chain (ETC) components at the mRNA and protein levels. In the cytoplasm, shows a 3'-to-5' exoribonuclease mediating mRNA degradation activity, degrades c-myc mRNA upon treatment with IFNB1/IFN-beta, resulting in a growth arrest in melanoma cells. Regulates the stability of specific mature miRNAs in melanoma cells, specifically and selectively degrades miR-221, preferentially. Plays also a role in RNA cell surveillance by cleaning up oxidized RNAs. Binds to the RNA subunit of ribonuclease P, MRP RNA and miR-221 microRNA.

    Gen-ID
    87178
    UniProt
    Q8TCS8
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