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RNF126 Antikörper (AA 51-150) (AbBy Fluor® 555)

RNF126 Reaktivität: Human, Maus WB, IF (cc), IF (p) Wirt: Kaninchen Polyclonal AbBy Fluor® 555
Produktnummer ABIN913807
  • Target Alle RNF126 Antikörper anzeigen
    RNF126 (Ring Finger Protein 126 (RNF126))
    Bindungsspezifität
    • 14
    • 6
    • 2
    • 1
    • 1
    • 1
    AA 51-150
    Reaktivität
    • 32
    • 19
    • 4
    • 2
    • 2
    • 1
    • 1
    Human, Maus
    Wirt
    • 31
    • 1
    Kaninchen
    Klonalität
    • 31
    • 1
    Polyklonal
    Konjugat
    • 9
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser RNF126 Antikörper ist konjugiert mit AbBy Fluor® 555
    Applikation
    • 22
    • 12
    • 12
    • 10
    • 3
    • 3
    • 3
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
    Kreuzreaktivität
    Human, Maus
    Homologie
    Rat,Cow
    Aufreinigung
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human RNF126
    Isotyp
    IgG
    Top Product
    Discover our top product RNF126 Primärantikörper
  • Applikationshinweise
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Konservierungsmittel
    ProClin
    Vorsichtsmaßnahmen
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    Haltbarkeit
    12 months
  • Target
    RNF126 (Ring Finger Protein 126 (RNF126))
    Andere Bezeichnung
    Rnf126 (RNF126 Produkte)
    Synonyme
    2610010O19Rik antikoerper, ring finger protein 126 antikoerper, RNF126 antikoerper, Rnf126 antikoerper
    Hintergrund

    Synonyms: E3 ubiquitin-protein ligase RNF126, RING finger protein 126, RNF126

    Background: E3 ubiquitin-protein ligase that regulates several biological processes through ubiquitination of various target proteins. Depending on the associated E2 ligase, mediates 'Lys-48'- and 'Lys-63'-linked polyubiquitination of substrates. Through their polyubiquitination, may play a role in the endosomal sorting and degradation of several membrane receptors including EGFR, FLT3, MET and CXCR4. May also be part of a BAG6-dependent quality control process ensuring that proteins of the secretory pathway that are mislocalized to the cytosol are degraded by the proteasome. May provide the ubiquitin ligase activity associated with the BAG6 complex and be responsible for ubiquitination of the mislocalized proteins and their targeting to the proteasome (PubMed:24981174). May also play a role in the endosomal recycling of IGF2R, the cation-independent mannose-6-phosphate receptor (PubMed:24275455). By ubiquitinating CDKN1A/p21 and targeting it for degradation, may also promote cell proliferation (PubMed:23026136). May monoubiquitinate AICDA (PubMed:23277564).

    Gen-ID
    55658
    UniProt
    Q9BV68
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