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SHoc2/Sur8 Antikörper (AA 36-120) (Biotin)

SHOC2 Reaktivität: Human, Maus, Ratte WB, ELISA, IHC (p), IHC (fro) Wirt: Kaninchen Polyclonal Biotin
Produktnummer ABIN915161
  • Target Alle SHoc2/Sur8 (SHOC2) Antikörper anzeigen
    SHoc2/Sur8 (SHOC2) (Leucine-rich repeat protein SHOC-2 (SHOC2))
    Bindungsspezifität
    • 14
    • 13
    • 10
    • 5
    • 2
    • 1
    • 1
    • 1
    • 1
    AA 36-120
    Reaktivität
    • 41
    • 27
    • 20
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    Human, Maus, Ratte
    Wirt
    • 41
    Kaninchen
    Klonalität
    • 41
    Polyklonal
    Konjugat
    • 14
    • 5
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser SHoc2/Sur8 Antikörper ist konjugiert mit Biotin
    Applikation
    • 37
    • 18
    • 13
    • 13
    • 5
    • 3
    • 2
    • 2
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
    Kreuzreaktivität
    Human, Maus, Ratte
    Homologie
    Dog,Cow,Sheep,Chicken
    Aufreinigung
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human SHOC2/Sur8
    Isotyp
    IgG
    Top Product
    Discover our top product SHOC2 Primärantikörper
  • Applikationshinweise
    WB 1:300-5000
    IHC-P 1:200-400
    IHC-F 1:100-500
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Konservierungsmittel
    ProClin
    Vorsichtsmaßnahmen
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20°C for 12 months.
    Haltbarkeit
    12 months
  • Target
    SHoc2/Sur8 (SHOC2) (Leucine-rich repeat protein SHOC-2 (SHOC2))
    Andere Bezeichnung
    SHOC2 (SHOC2 Produkte)
    Synonyme
    AU017287 antikoerper, Sur8 antikoerper, mKIAA0862 antikoerper, SIAA0862 antikoerper, SOC2 antikoerper, SUR8 antikoerper, si:ch211-159c12.3 antikoerper, si:ch211-197i12.3 antikoerper, zgc:152956 antikoerper, soc-2 (suppressor of clear) homolog (C. elegans) antikoerper, SHOC2 leucine-rich repeat scaffold protein antikoerper, SHOC2 leucine-rich repeat scaffold protein S homeolog antikoerper, SHOC2, leucine rich repeat scaffold protein antikoerper, Shoc2 antikoerper, shoc2.S antikoerper, SHOC2 antikoerper, shoc2 antikoerper
    Hintergrund

    Synonyms: Leucine-rich repeat protein SHOC-2, Leucine-rich repeat protein SHOC-2, Ras-binding protein Sur-8, KIAA0862, Leucine-rich repeat protein SHOC-2, Protein soc-2 homolog, Protein Sur-8 homolog, SHOC2, SHOC2_HUMAN.

    Background: Regulatory subunit of protein phosphatase 1 (PP1c) that acts as a M-Ras/MRAS effector and participates in MAPK pathway activation. Upon M-Ras/MRAS activation, targets PP1c to specifically dephosphorylate the 'Ser-259' inhibitory site of RAF1 kinase and stimulate RAF1 activity at specialized signaling complexes.Involvement in disease:Defects in SHOC2 are the cause of Noonan syndrome-like with loose anagen hair (NSLAH) . NSLAH children display macrocephaly, high forehead, hypertelorism, palpebral ptosis, low-set and posteriorly rotated ears, short and webbed neck and pectus anomalies. Affected subjects also have easily pluckable, sparse, thin and slow-growing hair.

    Gen-ID
    8036
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