TRIM33 Antikörper (AA 981-1127) (AbBy Fluor® 350)

Produktnummer ABIN917740

Produktdetails anti-TRIM33 Antikörper (AbBy Fluor® 350)

Target: TRIM33 (Tripartite Motif Containing 33 (TRIM33))

Bindungsspezifität: AA 981-1127

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TRIM33 Antikörper ist konjugiert mit AbBy Fluor® 350

Applikation: Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Kreuzreaktivität: Human, Maus, Ratte

Homologie: Dog,Cow,Pig,Horse,Chicken

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human TIF1 gamma

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: FCM 1:20-100
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Details zu TRIM33

Target: TRIM33 (Tripartite Motif Containing 33 (TRIM33))

Andere Bezeichnung: T1 gamma (TRIM33 Produkte)

Synonyme: TRIM33 antikoerper, ptc7 antikoerper, rfg7 antikoerper, tf1g antikoerper, tif1g antikoerper, tifgamma antikoerper, MGC146665 antikoerper, tif1gamma antikoerper, ECTO antikoerper, PTC7 antikoerper, RFG7 antikoerper, TF1G antikoerper, TIF1G antikoerper, TIF1GAMMA antikoerper, TIFGAMMA antikoerper, ecto antikoerper, 8030451N04Rik antikoerper, AI413936 antikoerper, Ecto antikoerper, Tif1g antikoerper, ectodermin antikoerper, mKIAA1113 antikoerper, cb1085 antikoerper, id:ibd2175 antikoerper, mon antikoerper, wu:fc17f10 antikoerper, zgc:136680 antikoerper, tripartite motif containing 33 antikoerper, tripartite motif containing 33 L homeolog antikoerper, tripartite motif-containing 33 antikoerper, TRIM33 antikoerper, trim33 antikoerper, trim33.L antikoerper, Trim33 antikoerper

Hintergrund:

Synonyms: ECTO, PTC7, RFG7, TF1G, TIF1G, TIFGAMMA, TIF1GAMMA, E3 ubiquitin-protein ligase TRIM33, Ectodermin homolog, RET-fused gene 7 protein, Protein Rfg7, Transcription intermediary factor 1-gamma, TIF1-gamma, Tripartite motif-containing protein 33, TRIM33, KIAA1113

Background: Acts as an E3 ubiquitin-protein ligase. Promotes SMAD4 ubiquitination, nuclear exclusion and degradation via the ubiquitin proteasome pathway. According to PubMed:16751102, does not promote a decrease in the level of endogenous SMAD4. May act as a transcriptional repressor. Inhibits the transcriptional response to TGF-beta/BMP signaling cascade. Plays a role in the control of cell proliferation. Its association with SMAD2 and SMAD3 stimulates erythroid differentiation of hematopoietic stem/progenitor (By similarity). Monoubiquitinates SMAD4 and acts as an inhibitor of SMAD4-dependent TGF-beta/BMP signaling cascade (Monoubiquitination of SMAD4 hampers its ability to form a stable complex with activated SMAD2/3 resulting in inhibition of TGF-beta/BMP signaling cascade).

Gen-ID: 51592

UniProt: Q9UPN9