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HBxAg Antikörper (AbBy Fluor® 488)

HBxAg Reaktivität: Hepatitis B Virus (HBV) WB, IF (cc), IF (p) Wirt: Kaninchen Polyclonal AbBy Fluor® 488
Produktnummer ABIN920133
  • Target Alle HBxAg Produkte
    HBxAg (Hepatitis B Virus X Antigen (HBxAg))
    Reaktivität
    • 21
    • 7
    • 7
    • 7
    • 4
    Hepatitis B Virus (HBV)
    Wirt
    • 16
    • 16
    Kaninchen
    Klonalität
    • 16
    • 16
    Polyklonal
    Konjugat
    • 12
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser HBxAg Antikörper ist konjugiert mit AbBy Fluor® 488
    Applikation
    • 23
    • 12
    • 12
    • 11
    • 4
    • 4
    • 3
    • 3
    • 2
    • 1
    Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
    Kreuzreaktivität
    Virus
    Kreuzreaktivität (Details)
    Hepatitis B virus
    Aufreinigung
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from Hepatitis B virus X protein
    Isotyp
    IgG
  • Applikationshinweise
    IF(IHC-P) 1:50-200
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    Haltbarkeit
    12 months
  • Target
    HBxAg (Hepatitis B Virus X Antigen (HBxAg))
    Andere Bezeichnung
    Hepatitis B Virus X Protein (HBxAg Produkte)
    Substanzklasse
    Viral Protein
    Hintergrund

    Synonyms: HBX, pre-X protein, HB-X, X protein, HBV X protein, X protein [Hepatitis B virus].

    Background: Multifunctional protein that may modulate protein degradation pathways, apoptosis, transcription, signal transduction, cell cycle progress, and genetic stability by directly or indirectly interacting with hosts factors. Does not seem to be essential for HBV infection. May be directly involved in development of cirrhosis and liver cancer (hepatocellular carcinoma). Most of cytosolic activities involve modulation of cytosolic calcium. The effect on apoptosis is controversial depending on the cell types in which the studies have been conducted. By binding to human DDB1, may affect cell viability and stimulate genome replication. May induce apoptosis by localizing in mitochondria and causing loss of mitochondrial membrane potential. May also modulate apoptosis by binding human CFLAR, a key regulator of the death-inducing signaling complex (DISC). Moderately stimulates transcription of many different viral and cellular transcription elements. Promoters and enhancers stimulated by HBx contain DNA binding sites for NF-kappa-B, AP-1, AP-2, c-EBP, ATF/CREB, or the calcium-activated factor NF-AT. May bind bZIP transcription factors like CREB1 (By similarity).

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