ZW10 Antikörper (AbBy Fluor® 647)

Produktnummer ABIN920494

Produktdetails anti-ZW10 Antikörper (AbBy Fluor® 647)

Target: ZW10 (Zw10 Kinetochore Protein (ZW10))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ZW10 Antikörper ist konjugiert mit AbBy Fluor® 647

Applikation: Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Homologie: Human,Mouse,Rat

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from mouse ZW10

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IF(IHC-P) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Details zu ZW10

Target: ZW10 (Zw10 Kinetochore Protein (ZW10))

Abstract: ZW10 Produkte

Synonyme: HZW10 antikoerper, KNTC1AP antikoerper, 6330566F14Rik antikoerper, MmZw10 antikoerper, zw10 kinetochore protein antikoerper, ZW10 antikoerper, Zw10 antikoerper

Hintergrund:

Synonyms: Centromere/kinetochore protein zw10, Centromere/kinetochore protein zw10 homolog, HZW 10, HZW10, Kinetochore associated homolog, KNTC1AP, MGC149821, Zeste White 10, Zeste white 10 homolog, ZW 10, ZW 10, centromere/kinetochore protein, ZW 10 kinetochore associated homolog, ZW10 Drosophila homolog centromere/kinetochore protein, ZW10 homolog centromere/kinetochore protein Drosophila, ZW10 homolog centromere/kinetochore protein, ZW10 kinetochore associated homolog, ZW10_MOUSE.

Background: The mitotic checkpoint ensures that chromosomes are divided equally between daughter cells and is a primary mechanism preventing the chromosome instability often seen in aneuploid human tumors. This gene encodes a protein that is one of many involved in mechanisms to ensure proper chromosome segregation during cell division. The encoded protein binds to centromeres during the prophase, metaphase, and early anaphase cell division stages and to kinetochore microtubules during metaphase. It is part of the MIS12 complex, which may be fundamental for kinetochore formation and proper chromosome segregation during mitosis. In mitotic human cells ZW10 resides in a complex with Rod and Zwilch, whereas another ZW10 partner, Zwint-1, is part of a separate complex of structural kinetochore components including Mis12 and Ndc80-Hec1. Zwint-1 is critical for recruiting ZW10 to unattached kinetochores. Depletion from human cells demonstrates that the ZW10 complex is essential for stable binding of a Mad1-Mad2 complex to unattached kinetochores. Thus, ZW10 functions as a linker between the core structural elements of the outer kinetochore and components that catalyze generation of the mitotic checkpoint-derived "stop anaphase" inhibitor.

Gen-ID: 9183