5HT1B Receptor Antikörper (N-Term)

Produktnummer ABIN926037

Produktdetails anti-5HT1B Receptor Antikörper

Target: 5HT1B Receptor (HTR1B) (Serotonin Receptor 1B (HTR1B))

Bindungsspezifität: N-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser 5HT1B Receptor Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Immunogen: HTR1 B antibody was raised in rabbit using the N terminal of HTR1 as the immunogen

Anwendungsinformationen

Applikationshinweise: WB: 1.25 µg/mL
Optimal conditions should be determined by the investigator.

Kommentare:

HTR1B Blocking Peptide, catalog no. 33R-5909, is also available for use as a blocking control in assays to test for specificity of this HTR1B antibody

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Konzentration: Lot specific

Buffer: Lyophilized powder. Add 100 µL of distilled water. Final antibody concentration is 1 mg/mL in PBS buffer.

Handhabung: Avoid repeated freeze/thaw cycles.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at 4 °C, following reconstitution, aliquot and store at -20 °C.

Details zu 5HT1B Receptor

Target: 5HT1B Receptor (HTR1B) (Serotonin Receptor 1B (HTR1B))

Andere Bezeichnung: HTR1B (HTR1B Produkte)

Hintergrund: The pathophysiology of depression remains enigmatic, although abnormalities that involve serotonin signaling have been implicated. The serotonin 1B receptor [5-hydroxytryptamine (5-HT1B) receptor] interacts with p11. p11 increases localization of 5-HT1B receptors at the cell surface. p11 is increased in rodent brains by antidepressants or electroconvulsive therapy, but decreased in an animal model of depression and in brain tissue from depressed patients. Overexpression of p11 increases 5-HT1B receptor function in cells and recapitulates certain behaviors seen after antidepressant treatment in mice. p11 knockout mice exhibit a depression-like phenotype and have reduced responsiveness to 5-HT1B receptor agonists and reduced behavioral reactions to an antidepressant. Synonyms: Polyclonal HTR1B antibody, Anti-HTR1B antibody, 5-hydroxytryptamine, serotonin receptor 1B antibody.

Pathways: JAK-STAT Signalweg, cAMP Metabolic Process, Regulation of G-Protein Coupled Receptor Protein Signaling, Feeding Behaviour, S100 Proteine