PSMC3IP Antikörper (C-Term)

Produktnummer ABIN928182

Produktdetails anti-PSMC3IP Antikörper

Target: PSMC3IP (PSMC3 Interacting Protein (PSMC3IP))

Bindungsspezifität: C-Term

Reaktivität: Maus, Human, Ratte, Hund, Rind (Kuh), Zebrafisch (Danio rerio), Xenopus laevis, Huhn

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PSMC3IP Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Kreuzreaktivität: Maus, Ratte (Rattus), Frosch, Hund, Huhn, Rind (Kuh), Zebrafisch (Brachydanio rerio)

Aufreinigung: Purified

Immunogen: PSMC3 IP antibody was raised in rabbit using the C terminal of PSMC3 P as the immunogen

Anwendungsinformationen

Applikationshinweise: WB: 0.2-1 µg/mL
Optimal conditions should be determined by the investigator.

Kommentare:

PSMC3IP Blocking Peptide, catalog no. 33R-7037, is also available for use as a blocking control in assays to test for specificity of this PSMC3IP antibody

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Konzentration: Lot specific

Buffer: Lyophilized powder. Add 50 µL of distilled water. Final antibody concentration is 1 mg/mL in PBS buffer.

Handhabung: Avoid repeated freeze/thaw cycles.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at 4 °C, following reconstitution, aliquot and store at -20 °C.

Details zu PSMC3IP

Target: PSMC3IP (PSMC3 Interacting Protein (PSMC3IP))

Andere Bezeichnung: PSMC3IP (PSMC3IP Produkte)

Hintergrund: PSMC3IP plays an important role in meiotic recombination. It stimulates DMC1-mediated strand exchange required for pairing homologous chromosomes during meiosis. The complex PSMC3IP/MND1 binds DNA, stimulates the recombinase activity of DMC1 as well as DMC1 D-loop formation from double-strand DNA. This complex stabilizes presynaptic RAD51 and DMC1 filaments formed on single strand DNA to capture double-strand DNA. This complex stimulates both synaptic and presynaptic critical steps in RAD51 and DMC1-promoted homologous pairing. It may inhibit HIV-1 viral protein TAT activity and modulate the activity of proteasomes through association with PSMC3. Synonyms: Polyclonal PSMC3IP antibody, Anti-PSMC3IP antibody, PSMC3 interacting protein antibody, GT198 antibody, HOP2 antibody, TBPIP antibody.