COCH Antikörper (N-Term)

Produktnummer ABIN929280

Produktdetails anti-COCH Antikörper

Target: COCH (Cochlin (COCH))

Bindungsspezifität: N-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser COCH Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Aufreinigung: Purified

Immunogen: COCH antibody was raised in rabbit using the N terminal of COCH as the immunogen

Anwendungsinformationen

Applikationshinweise: WB: 0.2-1 µg/mL
Optimal conditions should be determined by the investigator.

Kommentare:

COCH Blocking Peptide, catalog no. 33R-1253, is also available for use as a blocking control in assays to test for specificity of this COCH antibody

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Konzentration: Lot specific

Buffer: Lyophilized powder. Add 50 µL of distilled water. Final antibody concentration is 1 mg/mL in PBS buffer.

Handhabung: Avoid repeated freeze/thaw cycles.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at 4 °C, following reconstitution, aliquot and store at -20 °C.

Details zu COCH

Target: COCH (Cochlin (COCH))

Andere Bezeichnung: COCH (COCH Produkte)

Synonyme: AW122937 antikoerper, Coch-5B2 antikoerper, D12H14S564E antikoerper, COCH-5B2 antikoerper, COCH5B2 antikoerper, DFNA9 antikoerper, cochlin antikoerper, Coch antikoerper, COCH antikoerper

Hintergrund: The protein encoded by this gene is highly conserved in human, mouse, and chicken, showing 94% and 79% amino acid identity of human to mouse and chicken sequences, respectively. Hybridization to this gene was detected in spindle-shaped cells located along nerve fibers between the auditory ganglion and sensory epithelium. These cells accompany neurites at the habenula perforata, the opening through which neurites extend to innervate hair cells. This and the pattern of expression of this gene in chicken inner ear paralleled the histologic findings of acidophilic deposits, consistent with mucopolysaccharide ground substance, in temporal bones from DFNA9 (autosomal dominant nonsyndromic sensorineural deafness 9) patients. Mutations that cause DFNA9 have been reported in this gene. Alternative splicing results in multiple transcript variants encoding the same protein. Additional splice variants encoding distinct isoforms have been described but their biological validities have not been demonstrated. Synonyms: Polyclonal COCH antibody, Anti-COCH antibody, coagulation factor C homolog, cochlin, Limulus polyphemus antibody, COCH-5B2 antibody, COCH5B2 antibody, DFNA9 antibody.

Pathways: Sensory Perception of Sound