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MME Antikörper (Biotin)

Name: MME Antikörper (Biotin)
Brand: antibodies-online
SKU: ABIN93931
Price: 374.57 EUR
Availability: InStock

MME Reaktivität: Human FACS, IP Wirt: Maus Monoclonal MEM-78 Biotin

Flow cytometry surface staining pattern of human peripheral whole blood stained using anti-human CD10 (MEM-78) Biotin antibody (concentration in sample 12 μg/mL, Streptavidin APC). (MME Antikörper (Biotin))

FACS

Surface staining of NALM-6 human pre-B cell leukemia cell line with anti-human CD10 (MEM-78) PE. (MME Antikörper (Biotin))

FACS

Separation of neutrophil granulocytes stained anti-human CD10 (MEM-78) Biotin antibody (concentration in sample 12 μg/mL, Streptavidin APC, red-filled) from neutrophil granulocytes unstained by primary antibody (Streptavidin APC, black-dashed) in flow cytometry analysis (surface staining). (MME Antikörper (Biotin))

FACS

3 Abbildungen

(1 reference)

Produktnummer ABIN93931

Datenblatt (PDF)

Target Alle MME Antikörper anzeigen

MME (Membrane Metallo-Endopeptidase (MME))
Reaktivität
193

44

37

3

2

2

2

2

2

1

1

1

1
Human
Wirt
107

91

2
Maus
Passende Sekundärantikörper
Klonalität
117

82

2
Monoklonal
Konjugat
114

17

16

11

7

3

3

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
Dieser MME Antikörper ist konjugiert mit Biotin
Applikation
107

80

74

61

41

29

20

19

10

8

5

5

4

3

2

2

1

1

1

1

1

1

1
Flow Cytometry (FACS), Immunoprecipitation (IP)

Spezifität

The antibody MEM-78 reacts with an extracellular epitope CD10 antigen (CALLA - Common acute lymphatic leukemia antigen), a 100 kDa type II integral membrane protein.

Kreuzreaktivität (Details)

Human

Aufreinigung

Purified antibody is conjugated with biotin LC-NHS ester under optimum conditions and unconjugated antibody and free biotin are removed by size-exclusion chromatography.

Immunogen

NALM-6 human pre-B cell line

Klon

MEM-78

Isotyp

IgG1

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Applikationshinweise

Flow cytometry: Recommended dilution: 1 μg/mL.

Kommentare

The purified antibody is conjugated with Biotin-LC-NHS under optimum conditions. The reagent is free of unconjugated biotin.

Beschränkungen

Nur für Forschungszwecke einsetzbar
Konzentration

1 mg/mL

Buffer

Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Konservierungsmittel

Sodium azide

Vorsichtsmaßnahmen

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung

Do not freeze.
Avoid prolonged exposure to light.

Lagerung

4 °C

Informationen zur Lagerung

Store at 2-8°C. Do not freeze.
Angelisová, Drbal, Horejsí, Cerný: "Association of CD10/neutral endopeptidase 24.11 with membrane microdomains rich in glycosylphosphatidylinositol-anchored proteins and Lyn kinase." in: Blood, Vol. 93, Issue 4, pp. 1437-9, (1999) (PubMed).
Target

MME (Membrane Metallo-Endopeptidase (MME))

Andere Bezeichnung

CD10 (MME Produkte)

Substanzklasse

Chemical

Hintergrund

Membrane metalloendopeptidase,CD10 (neutral endopeptidase –, NEP, common acute lymphocytic leukemia antigen –, CALLA, membrane metallo-endopeptidase –, MME, enkefalinase) is a 100- kDa cell surface zinc metalloprotease, cleaving peptide bonds on the N-terminus of hydrophobic amino acids and inactivating multiple physiologically active peptids. CD10 is expressed on various normal cell types, including lymphoid precursor cells, germinal center B lymhocytes, and some epithelial cells, and its expression level serves as a marker for diagnostics of many carcinomas. CD10 is also a differentiation antigen for early B-lymphoid progenitors in the B-cell differentiation pathway and has a key role in regulation of growth, differentiation and signal transduction of many cellular systems.,CALLA, Neprilysin, Neutral endopeptidase, Enkephalinase, Atriopeptidase, MME

Gen-ID

4311

UniProt

P08473

Pathways

RTK Signalweg, Peptide Hormone Metabolism, Regulation of Systemic Arterial Blood Pressure by Hormones, Smooth Muscle Cell Migration