IGF2R Antikörper

Produktnummer ABIN94039

Produktdetails anti-IGF2R Antikörper

Target: IGF2R (Insulin-Like Growth Factor 2 Receptor (IGF2R))

Reaktivität: Human, Non-Human Primate

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser IGF2R Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Flow Cytometry (FACS), Immunoprecipitation (IP)

Spezifität: The antibody MEM-238 recognizes an extracellular epitope between amino acids 192-697 of CD222 (IGF2 receptor), a ubiquitously expressed 250 kDa multifunctional type I transmembrane protein. The majority of CD222 is found in the late endosomal/prelysosomal compartment, 5-10 % in the plasma membrane and the truncated (220 kDa) form of CD222 is present in human and bovine serum.

Kreuzreaktivität (Details): Human, Non-Human Primates

Aufreinigung: Purified by protein-A affinity chromatography.

Reinheit: > 95 % (by SDS-PAGE)

Immunogen: Recombinant Vaccinia virus encoding CD222.

Klon: MEM-238

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Flow cytometry: Extracellular and intracellular staining. Recommended dilution: 2-6 μg/mL.
Western blotting: Non-reducing conditions.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Do not freeze.

Lagerung: 4 °C

Informationen zur Lagerung: Store at 2-8°C. Do not freeze.

Referenzen für anti-IGF2R Antikörper (ABIN94039)

Schatzlmaier, Supper, Göschl, Zwirzitz, Eckerstorfer, Ellmeier, Huppa, Stockinger: "Rapid multiplex analysis of lipid raft components with single-cell resolution." in: Science signaling, Vol. 8, Issue 395, pp. rs11, (2015) (PubMed).

Leksa, Godár, Cebecauer, Hilgert, Breuss, Weidle, Horejsí, Binder, Stockinger: "The N terminus of mannose 6-phosphate/insulin-like growth factor 2 receptor in regulation of fibrinolysis and cell migration." in: The Journal of biological chemistry, Vol. 277, Issue 43, pp. 40575-82, (2002) (PubMed).

Details zu IGF2R

Target: IGF2R (Insulin-Like Growth Factor 2 Receptor (IGF2R))

Andere Bezeichnung: CD222 (IGF2R Produkte)

Synonyme: CD222 antikoerper, CIMPR antikoerper, M6P-R antikoerper, MPR1 antikoerper, MPRI antikoerper, AI661837 antikoerper, CI-MPR antikoerper, M6P/IGF2R antikoerper, Mpr300 antikoerper, mpri antikoerper, cd222 antikoerper, cimpr antikoerper, m6p-r antikoerper, insulin like growth factor 2 receptor antikoerper, insulin-like growth factor 2 receptor antikoerper, IGF2R antikoerper, Igf2r antikoerper, igf2r antikoerper

Hintergrund: Insulin like growth factor 2 receptorprovided,CD222 (CIMPR, cation-independent mannose 6-phosphate receptor, IGF2 receptor) is a ubiquitously expressed 250 kDa transmembrane protein. No more than 10 % of CD222 is present on the cell surface where it serves as a multifunctional receptor. Intracellular (major) fraction of CD222 is involved in transport of newly synthesized lysosomal enzymes modified by mannose 6-phosphate from Golgi apparatus to lysosomes. The cell surface CD222 binds and internalizes exogeneous mannose 6-phosphate-containing ligands. Importantly, CD222 is crutial for internalization and degradation of insulin-like growth factor 2, thus controling cell growth. CD222 also complexes CD87 (urokinase-type plasminogen-activator receptor), plasminogen and latent TGF-beta, last but not least CD222 serves as a receptor for heparanase and even for Listeria.,IGF2R, MPR1, CIMPR, MPR300, M6P-R

Gen-ID: 3482

UniProt: P11717