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Transferrin Receptor Antikörper

TFRC Reaktivität: Human FACS, IP, ICC Wirt: Maus Monoclonal MEM-75 unconjugated
Produktnummer ABIN94221
  • Target Alle Transferrin Receptor (TFRC) Antikörper anzeigen
    Transferrin Receptor (TFRC) (Transferrin Receptor (p90, CD71) (TFRC))
    Reaktivität
    • 201
    • 89
    • 30
    • 7
    • 6
    • 4
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Human
    Wirt
    • 114
    • 112
    • 34
    • 1
    • 1
    Maus
    Klonalität
    • 160
    • 100
    • 1
    Monoklonal
    Konjugat
    • 113
    • 29
    • 23
    • 15
    • 11
    • 5
    • 5
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser Transferrin Receptor Antikörper ist unkonjugiert
    Applikation
    • 155
    • 136
    • 76
    • 71
    • 53
    • 40
    • 23
    • 21
    • 20
    • 12
    • 7
    • 6
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Flow Cytometry (FACS), Immunoprecipitation (IP), Immunocytochemistry (ICC)
    Spezifität
    The antibody MEM-75 reacts with an extracellular epitope of CD71 antigen (transferrin receptor), a 95 kDa type II homodimeric transmembrane glycoprotein expressed on activated B and T lymphocytes, macrophages and erythroid precursors, it is lost on resting blood leukocytes. The antibody MEM-75 does not block binding of transferrin to the receptor.
    Kreuzreaktivität (Details)
    Human
    Aufreinigung
    Purified by protein-A affinity chromatography.
    Reinheit
    > 98 % (by SDS-PAGE)
    Immunogen
    NALM-6 human pre-B cell line
    Klon
    MEM-75
    Isotyp
    IgG1
  • Applikationshinweise
    Flow cytometry: Recommended dilution: 0.5-4 μg/mL.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Konzentration
    1 mg/mL
    Buffer
    Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Do not freeze.
    Lagerung
    4 °C
    Informationen zur Lagerung
    Store at 2-8°C. Do not freeze.
  • Beck, Balogh, Kis, Izsépi, Cervenak, László, Bíró, Liliom, Mocsár, Vámosi, Füst, Matko: "New cholesterol-specific antibodies remodel HIV-1 target cells' surface and inhibit their in vitro virus production." in: Journal of lipid research, Vol. 51, Issue 2, pp. 286-96, (2010) (PubMed).

  • Target
    Transferrin Receptor (TFRC) (Transferrin Receptor (p90, CD71) (TFRC))
    Andere Bezeichnung
    CD71 (TFRC Produkte)
    Synonyme
    Trfr antikoerper, LOC100219280 antikoerper, tfr antikoerper, cd71 antikoerper, tfr1 antikoerper, trfr antikoerper, CD71 antikoerper, T9 antikoerper, TFR antikoerper, TFR1 antikoerper, TR antikoerper, TRFR antikoerper, p90 antikoerper, 2610028K12Rik antikoerper, AI195355 antikoerper, AI426448 antikoerper, AU015758 antikoerper, E430033M20Rik antikoerper, Mtvr-1 antikoerper, Mtvr1 antikoerper, transferrin receptor antikoerper, TFRC antikoerper, Tfrc antikoerper, tfrc antikoerper
    Hintergrund
    Transferrin receptor,CD71 (transferrin receptor) is a type II transmembrane glycoprotein expressed as homodimer in erythroid blood cell line and in activated leukocytes. Upon binding of holotransferrin (complex of transferrin and iron ions), CD71 is internalized by clathrin-mediated endocytosis. Acidification of endosomes by vesicular membrane proton pumps leads to dissociation of iron ions, whereas transferrin (apotransferrin) remains associated with CD71 and recycles to the cell surface, where it is released upon exposure to normal pH . CD71 is also involved in uptake of non-transferrin bound iron.,TfR1, TfR, TR, Trfr, T9, p90, TFRC
    Gen-ID
    7037
    UniProt
    P02786
    Pathways
    Transition Metal Ion Homeostasis
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