CD72 Antikörper
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- Target Alle CD72 Antikörper anzeigen
- CD72 (CD72 Molecule (CD72))
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Reaktivität
- Human
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Wirt
- Maus
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Klonalität
- Monoklonal
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Konjugat
- Dieser CD72 Antikörper ist unkonjugiert
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Applikation
- Flow Cytometry (FACS), Immunoprecipitation (IP)
- Spezifität
- The mouse monoclonal antibody 3F3 recognizes an extracellular epitope of CD72, a 39-43 kDa type II membrane glycoprotein (C-type lectin family). CD72 is a pan-B cell marker expressed throughout the B lymphocytes diferentiation with the exception of plasma cells, it is also present on follicular dendritic cells.
- Kreuzreaktivität (Details)
- Human
- Aufreinigung
- Purified by protein-A affinity chromatography.
- Reinheit
- > 95 % (by SDS-PAGE)
- Immunogen
- Normal human lymphocytes from a lymph node.
- Klon
- 3F3
- Isotyp
- IgG2b
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- Applikationshinweise
- Flow cytometry: Recommended dilution: 1 μg/mL.
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Konzentration
- 1 mg/mL
- Buffer
- Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
- Konservierungsmittel
- Sodium azide
- Handhabung
- Do not freeze.
- Lagerung
- 4 °C
- Informationen zur Lagerung
- Store at 2-8°C. Do not freeze.
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CD100 on NK cells enhance IFNgamma secretion and killing of target cells expressing CD72." in: PLoS ONE, Vol. 2, Issue 9, pp. e818, (2007) (PubMed).
: "
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CD100 on NK cells enhance IFNgamma secretion and killing of target cells expressing CD72." in: PLoS ONE, Vol. 2, Issue 9, pp. e818, (2007) (PubMed).
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- Target
- CD72 (CD72 Molecule (CD72))
- Andere Bezeichnung
- CD72 (CD72 Produkte)
- Synonyme
- CD72c antikoerper, Ly-19 antikoerper, Ly-32 antikoerper, Ly-m19 antikoerper, Lyb-2 antikoerper, CD72b antikoerper, LYB2 antikoerper, CD72 antigen antikoerper, CD72 molecule antikoerper, Cd72 antikoerper, CD72 antikoerper
- Hintergrund
- CD72 Molecule,CD72 is a transmembrane glycoprotein expressed as a homodimer especially in B cells, but also in other antigen presenting cells such as dendritic cells and macrophages. Through one of its immunoreceptor tyrosine-based inhibitory motives (ITIMs), CD72 interacts with tyrosine phosphatase SHP-1, thereby suppressing B cell responsiveness. Binding of CD72 with its ligand CD100 (Sema4D) prevents BCR association and phosphorylation of CD72 and results in dissociation of SHP-1 from CD72, thus enables B cell activation.,LYB2
- Gen-ID
- 971
- UniProt
- P21854
- Pathways
- BCR Signaling
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