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p21 Antikörper
CDKN1A
Reaktivität: Human, Non-Human Primate
ELISA, IHC (p), ICC
Wirt: Maus
Monoclonal
WA-1
unconjugated
Produktdetails anti-p21 Antikörper
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Target
Alle p21 (CDKN1A) Antikörper anzeigen
p21 (CDKN1A)
(Cyclin-Dependent Kinase Inhibitor 1A (p21, Cip1) (CDKN1A))
Reaktivität
Alle Reaktivitäten für p21 Antikörper
Human, Non-Human Primate
Wirt
Alle Wirte für p21 Antikörper
Maus
Klonalität
Alle Klonalitäten für p21 Antikörper
Monoklonal
Konjugat
Alle Konjugate für p21 Antikörper
Dieser p21 Antikörper ist unkonjugiert
Applikation
Alle Applikationen für p21 Antikörper
ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC)
Spezifität
The antibody WA-1 reacts with p21 protein (Waf1, Cip1, SDI 1, intracellular antigen), a 21 kDa tumour suppressor, which inhibits the activity of cyclin-dependent family kinases and of proliferating cell nuclear antigen.
Kreuzreaktivität (Details)
Human, Non-Human Primates
Aufreinigung
Purified by protein-A affinity chromatography.
Reinheit
> 95 % (by SDS-PAGE)
Immunogen
Human p21 protein
Klon
WA-1
Isotyp
IgG1
Top Product
Discover our top product CDKN1A Primärantikörper
Alternativen
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anti-Cyclin-Dependent Kinase Inhibitor 1A (p21, Cip1) (CDKN1A) (AA 21-100) antibody
CDKN1A
Reaktivität: Human, Maus, Ratte, Schaf
WB, ELISA, FACS, IHC (p), IF (cc), IF (p), ICC, IHC (fro)
Wirt: Kaninchen
Polyclonal
unconjugated
Anwendungsinformationen
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Applikationshinweise
Immunohistochemistry (paraffin sections): Positive tissue: colon carcinoma.
Beschränkungen
Nur für Forschungszwecke einsetzbar
Handhabung
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Konzentration
1 mg/mL
Buffer
Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
Konservierungsmittel
Sodium azide
Vorsichtsmaßnahmen
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handhabung
Do not freeze.
Lagerung
4 °C
Informationen zur Lagerung
Store at 2-8°C. Do not freeze.
Referenzen für anti-p21 Antikörper (ABIN94444)
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Palumbo, Gogliettino, Cocca, Iannitti, Sandomenico, Ruvo, Balestrieri, Rossi, Palmieri : "APEH Inhibition Affects Osteosarcoma Cell Viability via Downregulation of the Proteasome. " in: International journal of molecular sciences , Vol. 17 , Issue 10 , (2017 ) (PubMed ).
Kolár, Murray, Scott, Harrison, Vojt?sek, Dusek : "Relation of Bcl-2 expression to androgen receptor, p21WAF1/CIP1, and cyclin D1 status in prostate cancer. " in: Molecular pathology : MP , Vol. 53 , Issue 1 , pp. 15-8 , (2000 ) (PubMed ).
Details zu p21
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Target
p21 (CDKN1A)
(Cyclin-Dependent Kinase Inhibitor 1A (p21, Cip1) (CDKN1A))
Andere Bezeichnung
p21Waf1 (CDKN1A Produkte )
Synonyme
CCND1 antikoerper, CDKN1A antikoerper, CAP20 antikoerper, CDKN1 antikoerper, CIP1 antikoerper, MDA-6 antikoerper, P21 antikoerper, SDI1 antikoerper, WAF1 antikoerper, p21CIP1 antikoerper, CDKI antikoerper, Cdkn1 antikoerper, Waf1 antikoerper, mda6 antikoerper, p21Cip1 antikoerper, p21WAF antikoerper, Cip1 antikoerper, UV96 antikoerper, p21 antikoerper, cip1 antikoerper, p16Xic2 antikoerper, sdi1 antikoerper, waf1 antikoerper, cap20 antikoerper, cdkn1 antikoerper, mda-6 antikoerper, p21cip1 antikoerper, si:ch1073-48m5.2 antikoerper, KRAS2 antikoerper, p21ras antikoerper, cyclin D1 antikoerper, cyclin dependent kinase inhibitor 1A antikoerper, cyclin-dependent kinase inhibitor 1A (P21) antikoerper, cyclin-dependent kinase inhibitor 1A antikoerper, cyclin-dependent kinase inhibitor 1A L homeolog antikoerper, cyclin-dependent kinase inhibitor 1 antikoerper, KRAS proto-oncogene, GTPase antikoerper, CCND1 antikoerper, CDKN1A antikoerper, Cdkn1a antikoerper, cdkn1a.L antikoerper, cki1 antikoerper, cdkn1a antikoerper, KRAS antikoerper
Hintergrund
Cyclin dependent kinase inhibitor 1A,The tumour suppressor p21Waf1 (wild-type p53-activated fragment 1, also known as Cip1, Cdk interacting protein, or SDI 1) is a cyclin-dependent kinase (Cdk) inhibitor, which is expressed by involvement of p53, Egr-1, AP2, STATs or other transcription factors upon various stimuli resulting in cell cycle arrest. Through its N-terminal domain p21Waf1 inhibits Cdk activity, whereas through the C-terminal domain it inhibits the activity of PCNA (proliferating cell nuclear antigen) to activate DNA replication. Cytosolic location of p21 counteracts its inhibitory activities.,CDKN1A, CIP1, CAP20
Gen-ID
1026
UniProt
P38936
Pathways
p53 Signalweg , PI3K-Akt Signalweg , Zellzyklus , AMPK Signaling , Fc-epsilon Rezeptor Signalübertragung , EGFR Signaling Pathway , Neurotrophin Signalübertragung , Mitotic G1-G1/S Phases , DNA Replication , Hepatitis C , Synthesis of DNA , Autophagie
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