p21 Antikörper
(2 Referenzen)-
- Target Alle p21 (CDKN1A) Antikörper anzeigen
- p21 (CDKN1A) (Cyclin-Dependent Kinase Inhibitor 1A (p21, Cip1) (CDKN1A))
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Reaktivität
- Human, Non-Human Primate
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Wirt
- Maus
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Klonalität
- Monoklonal
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Konjugat
- Dieser p21 Antikörper ist unkonjugiert
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Applikation
- ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC)
- Spezifität
- The antibody WA-1 reacts with p21 protein (Waf1, Cip1, SDI 1, intracellular antigen), a 21 kDa tumour suppressor, which inhibits the activity of cyclin-dependent family kinases and of proliferating cell nuclear antigen.
- Kreuzreaktivität (Details)
- Human, Non-Human Primates
- Aufreinigung
- Purified by protein-A affinity chromatography.
- Reinheit
- > 95 % (by SDS-PAGE)
- Immunogen
- Human p21 protein
- Klon
- WA-1
- Isotyp
- IgG1
- Top Product
- Discover our top product CDKN1A Primärantikörper
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anti-Cyclin-Dependent Kinase Inhibitor 1A (p21, Cip1) (CDKN1A) (AA 43-142) antibody
CDKN1A Reaktivität: Human WB, IF Wirt: Kaninchen Polyclonal unconjugated
anti-Cyclin-Dependent Kinase Inhibitor 1A (p21, Cip1) (CDKN1A) (AA 65-164) antibodyCDKN1A Reaktivität: Human WB, ELISA, IF, PLA Wirt: Maus Monoclonal 2F1 unconjugated
anti-Cyclin-Dependent Kinase Inhibitor 1A (p21, Cip1) (CDKN1A) antibodyKO Validated CDKN1A Reaktivität: Human WB, IHC Wirt: Kaninchen Monoclonal unconjugated
anti-Cyclin-Dependent Kinase Inhibitor 1A (p21, Cip1) (CDKN1A) (AA 1-164) antibodyCDKN1A Reaktivität: Human WB, IHC, IP, ICC Wirt: Kaninchen Polyclonal unconjugated
anti-Cyclin-Dependent Kinase Inhibitor 1A (p21, Cip1) (CDKN1A) (AA 1-100) antibodyCDKN1A Reaktivität: Synthetic WB, IHC (f) Wirt: Kaninchen Monoclonal unconjugated Recombinant Antibody
anti-Cyclin-Dependent Kinase Inhibitor 1A (p21, Cip1) (CDKN1A) (AA 21-100) antibodyCDKN1A Reaktivität: Human, Maus, Ratte, Schaf WB, ELISA, FACS, IHC (p), IF (cc), IF (p), ICC, IHC (fro) Wirt: Kaninchen Polyclonal unconjugated
anti-Cyclin-Dependent Kinase Inhibitor 1A (p21, Cip1) (CDKN1A) (AA 134-164), (C-Term) antibodyCDKN1A Reaktivität: Human WB, IF, FACS, IHC (p) Wirt: Kaninchen Polyclonal RB3180 unconjugated
anti-Cyclin-Dependent Kinase Inhibitor 1A (p21, Cip1) (CDKN1A) (AA 117-146), (C-Term) antibodyCDKN1A Reaktivität: Human, Maus WB, IF, IHC (p) Wirt: Kaninchen Polyclonal RB33282 unconjugated
anti-Cyclin-Dependent Kinase Inhibitor 1A (p21, Cip1) (CDKN1A) (pThr145) antibodyCDKN1A Reaktivität: Human WB, IHC (p), DB Wirt: Kaninchen Polyclonal RB07512 unconjugated
anti-Cyclin-Dependent Kinase Inhibitor 1A (p21, Cip1) (CDKN1A) antibodyCDKN1A Reaktivität: Human WB, IF, IHC, IHC (f) Wirt: Maus Monoclonal CIP1-823 unconjugated
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- Applikationshinweise
- Immunohistochemistry (paraffin sections): Positive tissue: colon carcinoma.
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Konzentration
- 1 mg/mL
- Buffer
- Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handhabung
- Do not freeze.
- Lagerung
- 4 °C
- Informationen zur Lagerung
- Store at 2-8°C. Do not freeze.
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: "APEH Inhibition Affects Osteosarcoma Cell Viability via Downregulation of the Proteasome." in: International journal of molecular sciences, Vol. 17, Issue 10, (2017) (PubMed).
: "Relation of Bcl-2 expression to androgen receptor, p21WAF1/CIP1, and cyclin D1 status in prostate cancer." in: Molecular pathology : MP, Vol. 53, Issue 1, pp. 15-8, (2000) (PubMed).
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: "APEH Inhibition Affects Osteosarcoma Cell Viability via Downregulation of the Proteasome." in: International journal of molecular sciences, Vol. 17, Issue 10, (2017) (PubMed).
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- Target
- p21 (CDKN1A) (Cyclin-Dependent Kinase Inhibitor 1A (p21, Cip1) (CDKN1A))
- Andere Bezeichnung
- p21Waf1 (CDKN1A Produkte)
- Hintergrund
- Cyclin dependent kinase inhibitor 1A,The tumour suppressor p21Waf1 (wild-type p53-activated fragment 1, also known as Cip1, Cdk interacting protein, or SDI 1) is a cyclin-dependent kinase (Cdk) inhibitor, which is expressed by involvement of p53, Egr-1, AP2, STATs or other transcription factors upon various stimuli resulting in cell cycle arrest. Through its N-terminal domain p21Waf1 inhibits Cdk activity, whereas through the C-terminal domain it inhibits the activity of PCNA (proliferating cell nuclear antigen) to activate DNA replication. Cytosolic location of p21 counteracts its inhibitory activities.,CDKN1A, CIP1, CAP20
- Gen-ID
- 1026
- UniProt
- P38936
- Pathways
- p53 Signalweg, PI3K-Akt Signalweg, Zellzyklus, AMPK Signaling, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Mitotic G1-G1/S Phases, DNA Replication, Hepatitis C, Synthesis of DNA, Autophagie
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