1700021I11Rik antikoerper, 2410018A12Rik antikoerper, 2610042E16Rik antikoerper, 2810046K12Rik antikoerper, AU044255 antikoerper, CENP-H antikoerper, ENP antikoerper, si:dkey-186m8.3 antikoerper, cenp-h antikoerper, centromere protein H antikoerper, centromere protein H pseudogene antikoerper, CENPH antikoerper, Cenph antikoerper, cenph antikoerper, LOC100356112 antikoerper, LOC101788801 antikoerper
Hintergrund
Centromere and kinetochore proteins play a critical role in centromere structure, kinetochore formation, and sister chromatid separation. The protein encoded by this gene colocalizes with inner kinetochore plate proteins CENP-A and CENP-C in both interphase and metaphase. It localizes outside of centromeric heterochromatin, where CENP-B is localized, and inside the kinetochore corona, where CENP-E is localized during prometaphase. It is thought that this protein can bind to itself, as well as to CENP-A, CENP-B or CENP-C. Multimers of the protein localize constitutively to the inner kinetochore plate and play an important role in the organization and function of the active centromere-kinetochore complex.Synonyms: CENPH, Centromere protein H, ICEN35, Interphase centromere complex protein 35